HARMINE

作品数：7被引量：27H指数：2
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相关领域：医药卫生更多>>
相关作者：朱毅何金龙刘伟程雪梅王长虹更多>>
相关机构：新疆医科大学天津医科大学空军军医大学（第四军医大学）浙江中医药大学更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Medicinal Plant》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Effects of 1-(2-chlorine)-phenyl-9-butyl-β-carboline(DH-330)on Cystic Echinococcosis in Mice in vivo
《Medicinal Plant》2022年第3期39-42,共4页Huijing GAO Xin WANG Cartiera KURBAN Aniwanr METIKURBAN Bei CHEN 
Supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (2020D01C245)
[Objectives]The paper was to evaluate the in vivo treatment efficacy of harmine derivative 1-(2-chloro)phenyl-9-butyl-β-carboline(DH-330)on mice cystic echinococcosis(CE).[Methods]Kunming mice were injected intraperi...
关键词：Harmine derivative Cystic echinococcosis Cyst weight Transmission electron microscope HISTOPATHOLOGY 
Heme perbxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine
《Chinese Journal of Natural Medicines》2022年第3期194-201,共8页WANG You-Xu CAO Ning GUAN Hui-Da CHENG Xue-Mei WANG Chang-Hong 
supported by the National Natural Science Foundation of China(Nos.82173885 and 81872933);the National Natural Science Foundation of Xinjiang Uyghur Autonomous Region of China(No.U1130303);the Technology Cooperation Projects of Science in Shanghai,China(No.20015800100);the Key Laboratory Open Project of Xinjiang Uyghur Autonomous Region(No.2019D04018).
Harmaline and harmine areβ-carboline alkaloids with effective pharmacological effects.Harmaline can be transformed into harmine after oral administration.However,enzymes involved in the metabolic pathway remain uncle...
关键词：HARMALINE HARMINE Oxidative dehydrogenation Heme peroxidases MYELOPEROXIDASE Horseradish peroxidase LACTOPEROXIDASE 
Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy被引量：1
《Acta Pharmacologica Sinica》2022年第1期50-63,共14页Jie Huang Yang Liu Jia-xin Chen Xin-ya Lu Wen-jia Zhu Le Qin Zi-xuan Xun Qiu-yi Zheng Er-min Li Ning Sun Chen Xu Hai-yan Chen 
We thank Chemical Biology Core Facility of SIBCB for technical supports.We also thank Ming Chen,Shu-jue Lan,Shuai Han,Hong-wei Zhao,Yun-qing Ci,and Rong-chao Yang(SIBCB)for their experimental assistance.This work was supported by the National Natural Science Foundation of China#82070391(to NS),#81500241(to CX);by the Innovative Research Team of High-Level Local Universities in Shanghai;by the National Key R&D Program of China 2018YFC2000202,the Haiju program of National Children’s Medical Center EK1125180102.
Harmine is aβ-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities,including antioxidant,anti-inflammatory,antitumor,anti-depressant,and anti-leishmanial cap...
关键词：cardiac hypertrophy HARMINE NE hESCs-derived cardiomyocytes INFLAMMATORY SHR 
Preparation, characterization and evaluation of liposomal doxorubicin and harmine that show synergistic activity in vitro
《Journal of Chinese Pharmaceutical Sciences》2017年第9期666-674,共9页Jiongxi Lei Shuangchen Cong Maoyuan Song Wenxi Zhang Guanghua Peng Yuanyuan Zhang Mengya Yin Jiaxing Wang Jiajia Li Xinru Li 
National Natural Science Foundation of China(Grant No.81541085)
A combinatory therapeutic system that simultaneously targets several independent pathways is preferred for the treatment of cancer. In our study, a combinatory liposomal delivery system containing doxorubicin （Dox） ...
关键词：DOXORUBICIN HARMINE Liposomes Combination therapy Synergistic effect 
Synthesis and cytotoxic activity of 3-phenyl-4-substituted-β-carbolines
《Chinese Chemical Letters》2012年第11期1230-1232,共3页Liu Liu Ying Ying Xu Ze Qi Yang Jian Nan Xiang Guang Yu Xu 
supported by NSFC(No.20602010);Scientific Research Fund of Hunan Provincial Education Department(No.10B061) and Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It wa...
关键词：β-Carboline SYNTHESIS Iodine-mediated cyclization CYTOTOXICITY HARMINE 
A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid "Harmine"被引量：18
《Asian Pacific Journal of Tropical Biomedicine》2012年第8期660-664,共5页K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel 
Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 18...
关键词：HARMINE ALKALOID PHARMACOLOGICAL activity Analytical technique Peganum harmala 
Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway被引量：11
《Hepatobiliary & Pancreatic Diseases International》2011年第6期599-604,共6页Ming-Rong Cao,Qiang Li,Zhi-Long Liu,Hui-Hui Liu,Wei Wang,Xiao-Li Liao,Yun-Long Pan and Jian-Wei Jiang Department of General Surgery,First Affiliated Hospital,Jinan University,Guangzhou 510632,China  Department of Anesthesiology,First Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510632,China  Department of Biochemistry,Medical College of Jinan University,Guangzhou 510632,China 
supported by grants from the Sci-Tech Project Foundation of Guangdong Province,China (2010B031600248);the National Natural Science Foundation of China (30772131)
BACKGROUND:Harmine has antitumor and antinociceptive effects,and inhibits human DNA topoisomerase.However no detailed data are available on the mechanisms of action of harmine in hepatocellular carcinoma.This study ai...
关键词：hepatocellular carcinoma HARMINE Bcl-2 protein CASPASE-3 APOPTOSIS 
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