A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid "Harmine"  

作　　者：K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel 

机构地区：[1]G.L.A Institute of Pharmaceutical Research [2]S.K.I.P.S [3]Department of Pharmaceutics,Institute of Technology,Banaras Hindu University

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2012年第8期660-664,共5页亚太热带生物医学杂志（英文版）

摘　　要：Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.Harmine, a beta-carboline alkaloid, is widely distributed in the plants, marine creatures, insects, mammalians as well as in human tissues and body fluids. Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring. Harmine has various types of pharmacological activities such as antimicrobial, antifungal, antitumor, cytotoxic, antiplasmodial, antioxidaant, antimutagenic, antigenotoxic and hallucinogenic properties. It acts on gamma–aminobutyric acid type A and monoamine oxidase A or B receptor, enhances insulin sensitivity and also produces vasorelaxant effect. Harmine prevents bone loss by suppressing osteoclastogenesis. The current review gives an overview on pharmacological activity and analytical techniques of harmine, which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.

关 键 词：HARMINE ALKALOID PHARMACOLOGICAL activity Analytical technique Peganum harmala 

分 类 号：R285[医药卫生—中药学]