Synthesis and cytotoxic activity of 3-phenyl-4-substituted-β-carbolines  

作　　者：Liu Liu Ying Ying Xu Ze Qi Yang Jian Nan Xiang Guang Yu Xu 

机构地区：[1]Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education),College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China [2]College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China

出　　处：《Chinese Chemical Letters》2012年第11期1230-1232,共3页中国化学快报（英文版）

基　　金：supported by NSFC(No.20602010);Scientific Research Fund of Hunan Provincial Education Department(No.10B061) and Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

摘　　要：A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.

关 键 词：β-Carboline SYNTHESIS Iodine-mediated cyclization CYTOTOXICITY HARMINE 

分 类 号：TQ464.2[化学工程—制药化工] O626.13[理学—有机化学]