THYMOCYTES

作品数：32被引量：43H指数：4
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Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity
《Cellular & Molecular Immunology》2023年第8期955-968,共14页Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho 
Funded by the“2022 Lupus Research Alliance(LRA)Lupus Innovation Award”.Institutional funding from the Portuguese Foundation for Science and Technology(FCT):projects NORTE-01-0145-FEDER-000029,POCI-01/0145-FEDER-016601,POCI-01-0145-FEDER-028772,and PTDC/MEC-REU/28772/2017(SSP);This study was co-funded by the European Union(ERC Synergy,GlycanSwitch,101071386);Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency.The study was also co-funded by the European Union,GlycanTrigger project,Grant Agreement No:101093997;Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.A grant was received from the Portuguese group of study in autoimmune diseases(NEDAI)to SSP.MMV(PD/BD/135452/2017,COVID/BD/152488/2022)received funding from the FCT.
T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of antigens.Glycosylation is a major posttranslational modification present in virtually all cells,incl...
关键词：N-glycosylation T-cell development THYMOCYTES GLYCOCALYX Inflammation 
The Possible Involvement of Apoptotic Decay of Terminal Deoxynucleotidyl Transferase-Positive Lymphocytes in the Reutilization of the Extracellular DNA Fragments by Surrounding Living Cells被引量：1
《Open Journal of Biophysics》2021年第4期371-382,共12页Aleksei N. Shoutko 
The migrating TdT+ thymocytes can die in other tissues, promoting the surrounding cells’ renewing likes holocrine secretion does. To clarify the role of TdT-enzyme for this function of progenitor lymphocyt...
关键词：THYMOCYTES Apoptosis Terminal Deoxynucleotidyl Transferase Extracellular Activity DNA Synthesis Precursors Reutilization 
Liver X receptorβis required for the survival of single-positive thymocytes by regulating IL-7Rαexpression
《Cellular & Molecular Immunology》2021年第8期1969-1980,共12页Huang Huang Xiaoping Wu Dongwei Meng Yizhou Feng Lan Zhou Zhenyu Liu Shupei Tang Xueqin Li Yi Cao Haiyang He Zhunyi Xie Jingbo Zhang Yongwen Chen Tingting Zhao Yuzhang Wu Xinyuan Zhou 
This work was supported by grants from the National Key Research and Development Program of China(No.2016YFA0502203 to X.Z.and No.2016YFA0502204 to Y.W.);the National Natural Science Foundation of China(No.81571537 to T.Z.,No.31770949 to X.Z.,No.31770972 to Z.X.,and No.81571604 to J.Z.);the Chongqing Basic and Frontier Research Project(No.cstc2015jcyjBX0086 to H.He.).
Liver X receptors(LXRs)are known as key transcription factors in lipid metabolism and have been reported to play an important role in T-cell proliferation.However,whether LXRs play a role in thymocyte development rema...
关键词：LXRβ IL-7Rα Single-positive thymocytes Cell survival Transcriptional regulation 
Alterations in thymocyte populations under conditions of endotoxin tolerance
《Chinese Medical Journal》2021年第15期1855-1865,共11页Yi-Jing Tao Juan-Juan Zhao Li-Hua Rao Song Yang Guo-Liang Zhang Meng-Meng Guo Chao Chen Lin Xu 
the Project of the Guizhou Provincial Department of Science and Technology(No.QKH-JC-2018-1428);the National Natural Science Foundation of China(No.31760258);the Guizhou Province Graduate Research Fund(No.YJSCXJH-2020-093).
Background:Endotoxin tolerance(ET)is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide(LPS)leads to dramatically elevated survival.Accumulating evidence has shown that peripher...
关键词：Immune tolerance THYMOCYTES T-cell receptor Gene rearrangement Adaptive immunity 
Sin1-mTORC2 signaling drives glycolysis of devetoping thymocytes
《Journal of Molecular Cell Biology》2019年第2期91-92,共2页Hongbo Chi 
Emerging studies highlight the import-ance of metabolic reprogramming in T cell development and function, although how these processes are regulated remains to be fully understood. Recent advances in dissecting the ro...
关键词：Sin1-mTORC2 THYMOCYTES GLYCOLYSIS 
Effects of an immunosuppressive active component of Periplocae Cortex (Periploca sepium Bge.) on positive selection of thymocytes in vitro被引量：1
《Journal of Traditional Chinese Medical Sciences》2018年第2期161-167,共7页Huifang Deng Hong Yang Dingnan Wang Baihui Zeng Shaohua Shi Han Yu Yunzhou Li Zongying Xu Xianggen Zhong 
This study was supported by the National Natural Science Foundation of China(30901909).
Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rhe...
关键词：IMMUNOSUPPRESSIVE active COMPONENT POSITIVE selection THYMOCYTES 
Integrative analysis for the role of long non-coding RNAs in radiation-induced mouse thymocytes responses被引量：2
《Acta Biochimica et Biophysica Sinica》2017年第1期51-61,共11页Hui Gao Zhuo Dong Wei Wei Lihong Shao Linlin Jin Yahui Lv Gang Zhao Shunzi Jin 
Long non-coding RNAs （IncRNAs） are a critical class of regulatory molecules involved in a variety of biological functions; however, their role in immune cells response to radiation is unknown. Therefore, in this stu...
关键词：long non-coding RNAs radiation effects mouse thymocytes response mechanism 
X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4^+CD8^+ thymocytes in recipient thymus
《The Journal of Biomedical Research》2012年第5期355-364,共10页Jinbo Li Hongquan Cai Jianliang Jin Qian Wang Dengshun Miao 
supported by an operating grant(No.BK2008440) to DSM from the Science and Technology Department of Jiangsu province,China
The aim of the present study was to determine whether the sensitivity of thymocytes to X-ray radiation depends on their proliferative states and whether radiation impairs the maturation of donor-derived thymocytes in ...
关键词：THYMUS radiation CD4^＋CD8^＋ thymocytes sensitivity donor cells 
Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections
《Open Journal of Immunology》2012年第1期25-39,共15页Yu Qiao Brian M. Gray Mohammed H. Sofi Laura D. Bauler Kathryn A. Eaton Mary X. D. O’Riordan Cheong-Hee Chang 
We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that ...
关键词：BACTERIAL Infection Innate-Like CD4 T Cells Immune Suppression 
c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2被引量：2
《Cell Research》2009年第3期340-347,共8页Xiaoming Wang Yafeng Zhang Gang Xiao Xiang Gao Xiaolong Liu 
T cells are derived from progenitor thymocytes, of which only a minority receive the appropriate TCR signal, undergo positive selection and mature. Owing to the very short lifespan of thymocytes, the prerequisite for ...
关键词：C-FOS BCL-2 SURVIVAL thymocyte development positive selection 
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