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作品数：1333被引量：1955H指数：18
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Hepatitis B virus genotype distribution and mutation patterns:Insights and clinical implications for hepatitis B virus positive patients
《World Journal of Experimental Medicine》2025年第2期72-82,共11页Manisha M Ratnaparkhi Chanda R Vyawahare Nageswari R Gandham 
Hepatitis B virus(HBV)infection is still a major worldwide health concern,contributing to chronic liver disorders like hepatocellular carcinoma(HCC).This review comprehensively analyzes HBV genotype distribution,mutat...
关键词：Chronic hepatitis Viral resistance Antiviral therapies Disease progression Personalized treatment 
A case of post-infectious anti-myelin oligodendrocyte glycoprotein antibody-positive optic neuritis
《International Journal of Ophthalmology(English edition)》2025年第4期751-752,共2页Yu Bin Son Kye-Hyung Kim Hee-Young Choi Hyeshin Jeon 
Dear Editor,Myelin oligodendrocyte glycoprotein(MOG)is a minor component of myelin,expressed on the external surface of oligodendrocytes in the central nervous system(CNS)[1].Anti-MOG antibodies(MOG-ab)have been impli...
关键词：NEURITIS MYELIN GLYCOPROTEIN 
Combining immune checkpoint inhibitors with standard treatment regimens in advanced human epidermal growth factor receptor-2 positive gastric cancer patients
《World Journal of Gastrointestinal Oncology》2025年第4期243-253,共11页Sheng-Hu Zhang Wan Li Xi-Yan Chen Le-Le Nie 
This study was approved by the ethics committee of the First People’s Hospital of Fuzhou City(No.FZ202103).
BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide,with its incidence and mortality rates ranking among the highest in gastrointestinal cancers.The overexpression or gene amplification of h...
关键词：ADVANCED Human epidermal growth factor receptor 2-positive Gastric cancer Standard treatment regimen Immune checkpoint inhibitors Efficacy Safety Prognosis Influencing factors 
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
《四川生理科学杂志》2025年第4期718-718,共1页Patrick Fernandes Rodrigues 
The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORγt+Tregs(pTregs),which prevent food intolerance and inflammatory bowel disease.Recent stud...
关键词：regulatory T cells inflammatory bowel diseaserecent dendritic cells type innate lymphoid cells ilc s ror t positive antigen presenting cells gut microbiota intestinal immune system food proteins 
POSITIVE GROUND STATE SOLUTIONS FOR A QUASILINEAR SCHRODINGER EQUATION
《数学杂志》2025年第2期95-110,共16页JIN Qing-fei 
Supported by Research Start-up Fund of Jianghan University(06050001).
This paper is concerned with the positive ground state solutions for a quasilinear Schrodinger equation with a Hardy-type term.We obtain positive ground state solutions for the given quasilinear Schrodinger equation b...
关键词：Quasilinear equation schrodinger equation positive ground state solutions variational methods 
The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer
《Acta Pharmacologica Sinica》2025年第4期1082-1096,共15页Qiu-yun Luo Jing Yang Tian Di Zeng-fei Xia Lin Zhang Wen-tao Pan Shan Shi Li-qiong Yang Jian Sun Miao-zhen Qiu Da-jun Yang 
supported by the National Natural Science Foundation of China(NSFC:82172748 and 82073377);the Guangdong Basic and Applied Basic Research Foundation(2024B1515020120 and 2023A1515110567);the Medical Scientific Research Foundation of Guangdong Province(A2024171).
HER2-positive gastric cancer has a poor prognosis,with a high incidence of drug resistance and a lack of effective treatments for drug-resistant patients.The exploration of the mechanism of resistance to HER2-targeted...
关键词：HER2-positive gastric cancer GSDME PYROPTOSIS APG-1252 
Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer:A systematic review and meta-analysis
《World Journal of Gastrointestinal Oncology》2025年第3期334-348,共15页Ming Cheng Yang Yu Takehiro Watanabe Yutaro Yoshimoto Sanae Kaji Yukinori Yube Munehisa Kaneda Hajime Orita Shinji Mine You-Yong Wu Tetsu Fukunaga 
the Clinical Medical Team Introduction Program of Suzhou,No.SZYJTD201804.
BACKGROUND Lymph node status is a critical prognostic factor in gastric cancer(GC),but stage migration may occur in pathological lymph nodes(pN)staging.To address this,alternative staging systems such as the positive ...
关键词：Gastric cancer Prognostic predictor Overall survival META-ANALYSIS Pathological lymph nodes Positive lymph node ratio Log odds of positive lymph nodes 
Galloping characteristics of catenary positive feeder considering aerodynamic damping
《Journal of Measurement Science and Instrumentation》2025年第1期142-153,共12页LI Yanzhe JIN Xianglong ZHAO Shanpeng ZHANG Youpeng WANG Sihua LI Wanrun 
supported by National Natural Science Foundation of China (No.51867013);Natural Science Foundation of Gansu Province (No.20JR5RA414)。
The purpose of this study is to analyze the galloping characteristics of the catenary positive feeder in fluctuating wind areas considering dynamic-wind angle of attack and aerodynamic damping.Firstly,the flow field m...
关键词：positive feeder aerodynamic damping fluctuating wind area galloping characteristics nonlinear dynamic analysis 
Impact of Laboratory Analytical Indicators on Positive Blood Culture Detection Rates: A Single Center Study
《Biomedical and Environmental Sciences》2025年第3期303-312,共10页Di Wang Lingli Liu Ruirui Ma Lijun Du Guixue Cheng Yali Liu Qiaolian Yi Yingchun Xu 
supported by grants from the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-074);Peking Union Medical College Hospital Research Funding for Postdoc(kyfyjj202320).
Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined...
关键词：Blood culture Laboratory analytical indicators Total pre-analytical time Time-to-detection PATHOGENS 
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop
《Acta Pharmacologica Sinica》2025年第3期592-605,共14页Shu-ting Yu Zhi-yong Sun Na Li Zhe-zhe Qu Chang-hao Wang Tian-tian Ju Ying-qi Liu Zhong-ting Mei Kui-wu Liu Mei-xi Lu Min Huang Ying Li Shun-kang Dou Jian-hao Jiang Yao-zhi Zhang Chuan-hao Huang Xiao-chen Pang Ying-qiong Jia Xian-hui Dong Fan Wu Yi Zhang Wan-hong Li Bao-feng Yang Wei-jie Du 
supported by grants from the National Natural Science Foundation of China(82273928,82473919,82330011,U21A20339);Natural Science Foundation for Distinguished Young Scholars of Heilongjiang Province(2024JQ0107);Youth Project of Scientific Research Institution of Heilongjiang Province(CZKYF2023-1-C047);CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003).
The N7-methylguanosine(m7G)methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis.In this study we investigated the role of Mettl1 in mouse cardiomyocytes injury and the underlying mechan...
关键词：cardiac ischemia/reperfusion injury Mettl1 m7G CYLD P53 UBIQUITINATION 
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