RADIORESISTANCE

作品数：53被引量：91H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：黄佳圆封冰王锐袁智勇黄桂春更多>>
相关机构：南京军区南京总医院赣州市人民医院中南大学天津医科大学更多>>
相关期刊：《Radiation Medicine and Protection》《IMP & HIRFL Annual Report》《Journal of Cancer Therapy》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金广东省自然科学基金河北省自然科学基金中国博士后科学基金更多>>
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LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis
《World Journal of Gastroenterology》2025年第16期49-65,共17页Qing Dai Tian-Yin Qu Jin-Lan Yang Jing Leng Lin Fang Qian-Qian Zhu Ke-Bi Wu Jie Wu Jing-Jing Ma Huang-Fei Yu 
Supported by the National Natural Science Foundation of China,No.81960506;Science and Technology Fund Project of Guizhou Provincial Health Commission,No.gzwkj2022-299;Key Projects of Zunyi Science and Technology Fund,No.zunshikeheHZzi(2023)24 and No.zunshikeheHZzi(2024)9.
BACKGROUND Radiotherapy is widely employed in colorectal cancer(CRC)treatment,but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure a...
关键词：Colorectal cancer LncRNA FTX Solute carrier family 7 member 11 Ferroptosis Redox RADIORESISTANCE 
Role of bioinformatics databases and tools in radiation biology
《Radiation Medicine and Protection》2024年第3期165-169,共5页Yizhe Gao Qingjie Liu 
supported by the National Natural Science Foundation of China(No.82173463).
Bioinformatics has become increasingly integral to radiation biology,also known as radiobiology,providing substantial support through data storage,conversion,visualization,and sharing.This review aims to deepen unders...
关键词：RADIOBIOLOGY BIOINFORMATICS RADIORESISTANCE Immune cell enrichment 
Regulator of G protein signaling 20 contributes to radioresistance of non-small cell lung cancer cells by suppressing pyroptosis
《Radiation Medicine and Protection》2024年第3期178-184,共7页Jialing Zhang Zhaoyan Jiang Xinglong Liu Xiaoya Jin Yan Pan Yang Bai Jianghong Zhang Chunlin Shao 
funded by the National Natural Science Foundation of China(No.12235004,12175044,32171235,12375338).
Objective:To investigate the potential role of the regulator of G protein signaling 20(RGS20)in radioresistance of non-small cell lung cancer(NSCLC).Methods:A total of 35 lung adenocarcinoma(LUAD)patients from The Can...
关键词：NSCLC RADIORESISTANCE RGS20 PYROPTOSIS 
LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer
《Oncology Research》2024年第8期1335-1346,共12页HAIQING HU HAO YANG SHUAISHUAI FAN XUE JIA YING ZHAO HONGRUI LI 
This study was supported by the Inner Mongolia Science and Technology Department Science and Technology Research Project(No.2021GG0270);National Natural Science Foundation of China(81860534);Natural Science Foundation of Inner Mongolia(2021MS08152);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT22004);Scientific and Technological Innovative Research Team for Inner Mongolia Medical University of Transformation Application of Organoid in Medical and Industrial Interdiscipline(YKD2022TD002);Major Project of Inner Mongolia Medical University(YKD2022 ZD002);Radiobiology System and Team Construction of Radiotherapy for Inner Mongolia Medical University(YKD2022XK014);Key Laboratoy of Radiation Physics and Biology of Inner Mongolia Medical University(PIKY2023030).
Long non-coding RNAs(lncRNAs)have been implicated in cancer progression and drug resistance development.Moreover,there is evidence that lncRNA HOX transcript antisense intergenic RNA(HOTAIR)is involved in colorectal c...
关键词：LncRNA HOTAIR CRC RADIORESISTANCE DNA damage repair ATR 
Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy
《Science China(Life Sciences)》2024年第7期1398-1412,共15页Shuxiang Wang Hongmei Cao Cui-Cui Zhao Qian Wang Dianyu Wang Jinjian Liu Lijun Yang Jianfeng Liu 
supported by the National Science Fund for Distinguished Young Scholars of China(82225026);the National Natural Science Foundation of China(82172082);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-042,2023-I2M-QJ-016)。
Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome ...
关键词：biomimetic nanosystem hypoxia alleviation glutathione consumption oxidative stress amplification DNA damage fixation RADIOSENSITIZATION 
Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments被引量：1
《World Journal of Stem Cells》2024年第5期604-614,共11页Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro Tel Marco Maria Fontanella Pier Paolo Panciani 
BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and radiotherapy.Glioma stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,...
关键词：Glioma stem cells CHEMORESISTANCE RADIORESISTANCE Molecular pathways Targeted therapies Systematic review 
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance被引量：1
《Cellular & Molecular Immunology》2024年第4期393-408,共16页Sujin Lee Yeunjung Ko Hyun Woo Lee Won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin Kim 
supported by National Research Foundation of Korea grant funded by the Korea government(MSIT)(2023R1A2C2004510);Korea Basic Science Institute(National Research Facilities and Equipment Center)grant(2020R1A6C101A191)of the Ministry of Education(Korea);the BK21 FOUR Program(Graduate School Innovation)of Sungkyunkwan University.
Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous subpopulations.Here,we showed that MZ B cells can be divid...
关键词：Marginal Zone B Cell CD80 AUTOREACTIVITY RADIORESISTANCE 
YWHAZ gene contributes to the radioresistance of oral squamous cell carcinoma cells
《Radiation Medicine and Protection》2024年第1期30-36,共7页Songling Hu Cong Chen Hengheng Chen Xin Yu Xiaofei Li Yang Bai Chunlin Shao 
supported by the National Nature Science Foundation of China(No.82203964);Science Talent Innovation Program of Shanghai Stomatological Hospital(No.SSH-2022-KJCX-B04),China.
Objective:To investigate the contribution of YWHAZ gene on the radioresistance and metastasis ability of oral squamous cell carcinoma(OSCC)cells.Mathods:The relationship between the expression level of YWHAZ gene and ...
关键词：Oral squamous cells Radiation sensitivity YWHAZ gene Cell migration 
Advances of radiotherapy combined with targeted therapy for nasopharyngeal carcinoma
《Radiation Medicine and Protection》2023年第4期197-203,共7页Xiaoyan Xu Hengzhao Zhuang Yijun Xu Zhongxu Xing Yang Jiao Lili Wang 
supported by the National Natural Science Foundation of China(82073476);the National Key R&D Program of China(2022YFC2503700,2022YFC2503703);Jiangsu Provincial Medical Key Discipline(ZDXK202235);Innovation Research Project of Medical and Industrial Cooperation in Suzhou(SLJ2021005),China.
Nasopharyngeal carcinoma is insidious at onset,prone to lymph node metastasis,and has a high rate of locally advanced disease at initial diagnosis.Radiotherapy combined with chemotherapy is the main treatment for loca...
关键词：Nasopharyngeal carcinoma RADIOTHERAPY Targeted therapy RADIORESISTANCE RADIOSENSITIVITY ANGIOGENESIS 
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling
《Signal Transduction and Targeted Therapy》2023年第11期5404-5416,共13页Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno Tiago Tavares Daniela Barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo 
External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been accomplished.However,RT resistance can arise and result in long-term recurrence...
关键词：TP53 DAMAGE cancer 
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