Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments  

作　　者：Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro Tel Marco Maria Fontanella Pier Paolo Panciani 

机构地区：[1]Division of Neurosurgery,Department of Medical and Surgical Specialties,Radiological Sciences and Public Health,University of Brescia,Brescia 25123,Italy [2]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy [3]Neurosurgery Unit,Department of Head-Neck and NeuroScience,University Hospital of Udine,Udine 33100,Italy [4]Clinic of Maxillofacial Surgery,Department of Head-Neck and NeuroScience,University Hospital of Udine,Udine 33100,Italy

出　　处：《World Journal of Stem Cells》2024年第5期604-614,共11页世界干细胞杂志（英文版）（电子版）

摘　　要：BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and radiotherapy.Glioma stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and plasticity.Recent studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular states.Resistance mechanisms can involve different cellular pathways,most of which have been recently reported in the literature.Despite progress,targeted therapeutic approaches lack consensus due to GSCs’high plasticity.AIM To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying mechanisms.METHODS A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,2023.The search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text analysis.Among them,201 were deemed eligible after excluding 168 for various reasons.The temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma characteristics.Pathway analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance development.Targeted molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette G2(12.1%)as frequent tar

关 键 词：Glioma stem cells CHEMORESISTANCE RADIORESISTANCE Molecular pathways Targeted therapies Systematic review 

分 类 号：R457.7[医药卫生—治疗学]