The immune system well illustrates the need for balance between aggression and tolerance:mechanisms are needed to drive the production of antibodies effective against pathogens whilst preventing the emergence of antib...
supported by National Research Foundation of Korea grant funded by the Korea government(MSIT)(2023R1A2C2004510);Korea Basic Science Institute(National Research Facilities and Equipment Center)grant(2020R1A6C101A191)of the Ministry of Education(Korea);the BK21 FOUR Program(Graduate School Innovation)of Sungkyunkwan University.
Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous subpopulations.Here,we showed that MZ B cells can be divid...
supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(No.NRF-2019R1A2C2006717).
In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells,many autoreactive B cells actually escape clonal deletion and develop into mature B cells.These autorea...
Introduction Urticaria is a common disease in dermatology.Physical urticarias are a group of urticaria that are induced by various physical stimulations,including shear force,cold,heat,pressure,and solar and vibratory...
Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to F...