RADIOSENSITIZATION

作品数：61被引量：291H指数：7
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Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor
《Chinese Chemical Letters》2025年第2期234-241,共8页Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu 
funded by a grant from Technology Project of Science and technology department of Sichuan province(No.2018SZ0021)。
It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need ...
关键词：FISETIN Polymetric micelles Radiotherapy RADIOSENSITIZER Platelet-derived growth factor receptor-β 
Semen podocarpi extract enhances radiosensitivity in nasopharyngeal carcinoma cells via Raf/MEK/ERK signaling pathway
《Asian Pacific Journal of Tropical Biomedicine》2025年第2期75-84,共10页Fan-Yan Zeng Zeng-Qiong Huang Yong-Cu Sun Xiao-Dong Zhu 
supported by the Project of Administration of Traditional Chinese Medicine of Guangxi Zhuang Autonomous Region(grant number GZSY22-69);the Middle/Young aged Teachers’Research Ability Improvement Project of Guangxi Higher Education(grant number 2024KY0120).
Objective:To investigate the chemical components of Semen podocarpi extract(SPE)and its effect on nasopharyngeal carcinoma cells and CNE-2R cells.Methods:Chemical components in SPE were identified by UPLC-MS/MS.CCK-8 ...
关键词：Podocarpus macrophyllus Nasopharyngeal carcinoma RADIOSENSITIZATION Chemical composition Inumakilactone Podocarpus flavone 
Preparation of water-soluble tantalum nanoparticles and their radiosensitization application
《Tungsten》2024年第4期748-758,共11页Wang Zhang Shuang-Long Du Zhi-Guo Zhang Tao Wang Chun-Jian Su Xing-Hua Dong Shuang Zhu Zhan-Jun Gu 
supported by the National Key R&D Program of China(Nos.2020YFA0710702 and 2021YFA1201200);the National Science Foundation of China(Nos.22375205,51705295 and 52103337);Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000);Directional Institutionalized Scientific Research Platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences,Beijing Natural Science Foundation(No.2222087);Shandong Provincial Natural Science Foundation of China(ZR2022ME032);the Support Program for Youth Innovation Technology in Colleges and Universities of Shandong Province(2019KJB015)。
Radiation therapy(RT)that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment method.However,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the t...
关键词：Tantalum nanoparticles Sodium hexametaphosphate Mechanochemical method Radiotherapy sensitization 
Enhancing tumor radiotherapy sensitivity through metal nanomaterials:A comprehensive review
《Malignancy Spectrum》2024年第4期243-262,共20页Susu Xiao Xiaoxiao Wang Bo Chen Min Mu Bo Han Nianyong Chen Gang Guo 
supported by the Science and Technology Plan Project of Bingtuan(2023AB047);the National Natural Sciences Foundation of China(31971308,82102767,and U1903211);the National S&T Major Project(2019ZX09301-147);the Natural Science Foundation of Sichuan Province(2023NSFSC1866);Sichuan Science and Technology Program(2022YFS0007);Luzhou Science and Technology Plan(2018CDLZ-10).
Radiotherapy(RT)plays a crucial role in tumor treatment and is an indispensable therapeutic approach.However,ionizing radiation often damages the normal tissues surrounding the tumor.Therefore,there is an urgent need ...
关键词：RADIOTHERAPY NANOMATERIALS RADIOSENSITIZATION high-Z metal TUMOR 
STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses
《National Science Review》2024年第7期183-198,共16页Taokun Luo Xiaomin Jiang Yingjie Fan Eric Yuan Jinhong Li Langston Tillman Wenbin Lin 
funding from the National Cancer Institute(1R01CA253655);the University of Chicago Medicine Comprehensive Cancer Center(NIH CCSG:P30 CA014599).
Radiotherapy is widely used for cancer treatment,but its clinical utility is limited by radioresistance and its inability to target metastases.Nanoscale metal-organic frameworks(MOFs)have shown promise as high-Z nanor...
关键词：metal-organic framework RADIOSENSITIZATION STING agonist artificial leukocytoid structures immune hotspots immunotherapy nanomedicine 
Clobetasol propionate,a Nrf-2 inhibitor,sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis被引量：1
《Acta Pharmacologica Sinica》2024年第7期1506-1519,共14页Archita Rai Raghavendra S.Patwardhan Sundarraj Jayakumar Pradnya Pachpatil Dhruv Das Girish Ch.Panigrahi Vikram Gota Sejal Patwardhan Santosh K.Sandur 
Combining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy for radioresistant lung cancer.Here,the radiosensitizing efficacy of a synthetic glucocorticoid clobetasol propionate(CP)in...
关键词：clobetasol propionate RADIOSENSITIZATION iron homeostasis lipid peroxidation non-small cell lung carcinoma GLUCOCORTICOID 
Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy
《Science China(Life Sciences)》2024年第7期1398-1412,共15页Shuxiang Wang Hongmei Cao Cui-Cui Zhao Qian Wang Dianyu Wang Jinjian Liu Lijun Yang Jianfeng Liu 
supported by the National Science Fund for Distinguished Young Scholars of China(82225026);the National Natural Science Foundation of China(82172082);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-042,2023-I2M-QJ-016)。
Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome ...
关键词：biomimetic nanosystem hypoxia alleviation glutathione consumption oxidative stress amplification DNA damage fixation RADIOSENSITIZATION 
Targeting the organelle for radiosensitization in cancer radiotherapy被引量：1
《Asian Journal of Pharmaceutical Sciences》2024年第2期52-71,共20页Xiaoyan Sun Linjie Wu Lina Du Wenhong Xu Min Han 
supported by the National Natural Science Foundation of China(No.82172186);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160030);the National Natural Science Foundation of China(No.82373206,No.82073332);the National Key Research and Development Program of China(No.2022YFE0107800).
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation ene...
关键词：Cancer radiotherapy Organelle-target RADIOSENSITIZATION Boron neutron capture therapy NANOMEDICINES 
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy被引量：2
《Acta Pharmaceutica Sinica B》2024年第4期1787-1800,共14页Yupeng Wang Lina Wang Tao Li Min Ouyang Hejian Xiong Dongfang Zhou 
This work is supported by grants from the National Natural Science Foundation of China(Nos.22275081,and 82372117);Guangdong Basic and Applied Basic Research Foundation(2021B1515120065,China);Guangzhou Science and Technology Bureau(202206010068);the Natural Science Foundation of Hebei Province(E2023205004,China);China Postdoctoral Science Foundation(2022M711532 and 2022T150302).
Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant tumors.In particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the...
关键词：Bimetallic nanoparticles Radio-immunotherapy Cascade sensitizing amplifier Oxaliplatin Fenton-typeHaber-Weiss reaction RADIOSENSITIZATION Immunogenic cell death Radio-resistance 
Hexyl-pentynoic acid serves as a novel radiosensitizer for breast cancer by inhibiting UCHL3-dependent Rad51 deubiquitination
《Radiation Medicine and Protection》2023年第4期204-213,共10页Zuchao Cai David Lim Beidi Jia Guochao Liu Wenwen Ding Zhendong Wang Zhujun Tian Junxuan Peng Fengmei Zhang Chao Dong Zhihui Feng 
supported by grants from Zhejiang Provincial Natural Science Foundation of China(LQ23H14003);National Natural Science Foundation of China(81472800,82173460);Department of Science and Technology of Shandong Province(2019GSF108083);Zhejiang Provincial Postdoctoral Scientific Research Project Funding(ZJ2022076),China.
Objective:To investigate the effects and underlying mechanism of 2-hexyl-4-pentynoic acid(HPTA),a derivative of valproic acid(VPA),on radiotherapy in breast cancer.Methods:MCF7 cells and 7,12-dimethylbenz-[α]-anthrac...
关键词：2-hexyl-4-pentynoic acid RADIOSENSITIZATION UCHL3 RAD51 Homologous recombination DEUBIQUITINATION 
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