FISETIN

作品数:16被引量:45H指数:4
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相关领域:医药卫生更多>>
相关作者:陈静芳王迎王建国李泽信李荣更多>>
相关机构:长沙市中心医院长沙市疾病预防控制中心遂宁市中心医院中南大学更多>>
相关期刊:《Hepatobiliary & Pancreatic Diseases International》《Asian Pacific Journal of Tropical Biomedicine》《Food Science and Human Wellness》《北京日化》更多>>
相关基金:国家自然科学基金重庆市自然科学基金内蒙古自治区自然科学基金国家教育部博士点基金更多>>
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Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor
《Chinese Chemical Letters》2025年第2期234-241,共8页Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu 
funded by a grant from Technology Project of Science and technology department of Sichuan province(No.2018SZ0021)。
It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need ...
关键词:FISETIN Polymetric micelles Radiotherapy RADIOSENSITIZER Platelet-derived growth factor receptor-β 
A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
《Animal Models and Experimental Medicine》2024年第5期591-605,共15页Mohammad Yasin Zamanian Niloofar Taheri Montather FRamadan Yasser Fakri Mustafa Safa Alkhayyat Klunko Nataliya Sergeevna Hashem OAlsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar 
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and veget...
关键词:apoptosis colorectal cancer FISETIN i nflammation p53 pathway 
A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate被引量:1
《Food Science and Human Wellness》2024年第2期688-697,共10页Shuai Hou Chutong Lai Yukun Song Haitao Wang Jialu Ni Mingqian Tan 
supported by Dalian Youth Science and Technology Star Project(2020RQ121);the National Science Fund for Distinguished Young Scholars of China(31925031);Doctoral Scientific Research Foundation of Liaoning Province(2020-BS-211);Liaoning Province Education Administration(J2020101)。
Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend longevity.The natural flavonol fisetin has been shown to antagonize senescen...
关键词:FISETIN Nanoparticle Cellular senescence Targeted delivery 
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis被引量:6
《Acta Pharmacologica Sinica》2024年第1期150-165,共16页Bo Wang Li-na Yang Le-tian Yang Yan Liang Fan Guo Ping Fu Liang Ma 
supported by the Science/Technology Project of Sichuan Province(2021YFQ0027 and 2022YFS0589);the Health Commission of Sichuan Province(20PJ048).The graphical abstract was created with a free version of Biorender.com under agreement number EL24NF7RFD.
Kidney fibrosis is the hallmark of chronic kidney disease(CKD)progression,whereas no effective anti-fibrotic therapies exist.Recent evidence has shown that tubular ferroptosis contributes to the pathogenesis of CKD wi...
关键词:chronic kidney disease kidney fibrosis tubular epithelial cell ferroptosis FISETIN 
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway被引量:2
《Acta Pharmacologica Sinica》2023年第10期2065-2074,共10页Ting-feng Zou Zhi-gang Liu Pei-chang Cao Shi-hong Zheng Wen-tong Guo Tian-xiang Wang Yuan-li Chen Ya-jun Duan Qing-shan Li Chen-zhong Liao Zhou-ling Xie Ji-hong Han Xiao-xiao Yang 
supported by the National Natural Science Foundation of China(NSFC)Grants 81973316 to JHH;the Major Special Science and Technology Project of Anhui Province(202003a07020015)to QSL;the Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of Human Development and Reproductive Regulation(2021XHY01)to XXY.
Diabetes-related vascular complications include diabetic cardiovascular diseases (CVD), diabetic nephropathy (DN) and diabetic retinopathy, etc. DN can promote the process of end-stage renal disease. On the other hand...
关键词:diabetic nephropathy fibrosis ATHEROSCLEROSIS TGFβ/(Smad2/3) CD36 FISETIN LDLR−/−mice HK-2 cells 
非瑟酮对LTA诱导小鼠子宫内膜炎症反应的影响被引量:1
《中国兽医学报》2023年第3期592-597,共6页沈菩秀 李刚 于井成 闫琛博 杨德新 王新庄 
国家重点研发计划资助项目(2018YFD0501800)。
为探究非瑟酮(Fisetin)对金黄色葡萄球菌脂磷壁酸(lipid teichoic acid,LTA)诱导的子宫内膜炎症反应的影响,试验选取20只8~10周龄的健康雌性昆明小鼠,随机分为4组,每组5只,包括对照组、LTA模型组、LTA+Fisetin(25 mg/kg)组、LTA+Fisetin...
关键词:小鼠 子宫内膜炎 脂磷壁酸(LTA) 非瑟酮(Fisetin) 
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway被引量:14
《Hepatobiliary & Pancreatic Diseases International》2021年第4期352-360,共9页Jun-Liang Pu Zuo-Tian Huang Yun-Hai Luo Tong Mou Ting-Ting Li Zhong-Tang Li Xu-Fu Wei Zhong-Jun Wu 
This study was supported by grants from the National Natural Science Foundation of China(81672959,81873592 and 81703063);the Science and Technology Commission Foundation of Chongqing,China(cstc2019jscx-gksb X0005);the Natural Science Foundation of Chongqing,China(cstc2018jscx-msyb X0133);the graduate tu-tor team construction project of Chongqing Municipal Education Commission Foundation,China(dstd201801).
Background: Hepatic ischemia-reperfusion(I/R) injury(IRI) represents a crucial challenge in liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties. This study aimed to examine w...
关键词:FISETIN Hepatic ischemia-reperfusion injury GSK3βAMPK NLRP3 
Fisetin对缺血再灌注肝脏氧化应激性损伤的保护作用被引量:3
《河南医学高等专科学校学报》2021年第1期1-5,共5页李泽信 王霄 王迎 张妤 李荣 王建国 
新乡医学院第一附属医院青年基金资助项目(QN-2017-B001);河南省医学科技攻关联合共建项目(LHGJ20200495)。
目的探讨3,3′4′7-四羟基黄酮(Fisetin)减轻缺血再灌注(ischemia/reperfusion,I/R)肝脏氧化应激性损伤的作用及可能机制。方法18只C57BL/6雄性小鼠随机分为Sham组、I/R组和I/R+Fisetin组,各6只。I/R组和I/R+Fisetin组小鼠建立肝脏I/R模...
关键词:肝脏缺血再灌注损伤 3 3′4′7-四羟基黄酮 活性氧自由基 氧化应激性损伤 大鼠 
Pharmacological aspects of fisetin
《Asian Pacific Journal of Tropical Biomedicine》2021年第1期1-9,共9页Lucia Dwi Antika Rita Marleta Dewi 
Over the past decades,epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health.Fisetin(3,3’,4’,7-tetrahydroxyflavone)is a hydrophobic polyphenolic compou...
关键词:FISETIN Anti-inflammatory ANTI-DIABETIC Anti-carcinogenic ANTI-OSTEOPOROSIS Cardioprotective activity 
Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling被引量:11
《Acta Pharmacologica Sinica》2020年第10期1348-1356,共9页Hai-feng Zhang Hai-bo Zhang Xue-ping Wu Ya-ling Guo Wei-dong Cheng Feng Qian 
supported by the Natural Science Research Project of Education Office of Anhui Province(KJ2019A0300);The National Key Clinical Specialty Construction Project of Pulmonary Critical Care Medicine(2012-649);The Key Research and Development Program of Anhui Province(1804h08020287);National Natural Science Foundation of China(81673791,81973329,81773741,and 81573438).
Sepsis-induced multiple organ dysfunction and inflammatory response are life-threatening symptoms without effective treatment.Fisetin,a dietary flavonoid extracted from berries and family Fabaceae,has displayed neurop...
关键词:FISETIN sepsis multiple organ dysfunction inflammation mouse cecum ligation and puncture(CLP)model macrophages 
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