funded by a grant from Technology Project of Science and technology department of Sichuan province(No.2018SZ0021)。
It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need ...
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and veget...
supported by Dalian Youth Science and Technology Star Project(2020RQ121);the National Science Fund for Distinguished Young Scholars of China(31925031);Doctoral Scientific Research Foundation of Liaoning Province(2020-BS-211);Liaoning Province Education Administration(J2020101)。
Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend longevity.The natural flavonol fisetin has been shown to antagonize senescen...
supported by the Science/Technology Project of Sichuan Province(2021YFQ0027 and 2022YFS0589);the Health Commission of Sichuan Province(20PJ048).The graphical abstract was created with a free version of Biorender.com under agreement number EL24NF7RFD.
Kidney fibrosis is the hallmark of chronic kidney disease(CKD)progression,whereas no effective anti-fibrotic therapies exist.Recent evidence has shown that tubular ferroptosis contributes to the pathogenesis of CKD wi...
supported by the National Natural Science Foundation of China(NSFC)Grants 81973316 to JHH;the Major Special Science and Technology Project of Anhui Province(202003a07020015)to QSL;the Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of Human Development and Reproductive Regulation(2021XHY01)to XXY.
Diabetes-related vascular complications include diabetic cardiovascular diseases (CVD), diabetic nephropathy (DN) and diabetic retinopathy, etc. DN can promote the process of end-stage renal disease. On the other hand...
This study was supported by grants from the National Natural Science Foundation of China(81672959,81873592 and 81703063);the Science and Technology Commission Foundation of Chongqing,China(cstc2019jscx-gksb X0005);the Natural Science Foundation of Chongqing,China(cstc2018jscx-msyb X0133);the graduate tu-tor team construction project of Chongqing Municipal Education Commission Foundation,China(dstd201801).
Background: Hepatic ischemia-reperfusion(I/R) injury(IRI) represents a crucial challenge in liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties. This study aimed to examine w...
Over the past decades,epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health.Fisetin(3,3’,4’,7-tetrahydroxyflavone)is a hydrophobic polyphenolic compou...
supported by the Natural Science Research Project of Education Office of Anhui Province(KJ2019A0300);The National Key Clinical Specialty Construction Project of Pulmonary Critical Care Medicine(2012-649);The Key Research and Development Program of Anhui Province(1804h08020287);National Natural Science Foundation of China(81673791,81973329,81773741,and 81573438).
Sepsis-induced multiple organ dysfunction and inflammatory response are life-threatening symptoms without effective treatment.Fisetin,a dietary flavonoid extracted from berries and family Fabaceae,has displayed neurop...