A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate  

作　　者：Shuai Hou Chutong Lai Yukun Song Haitao Wang Jialu Ni Mingqian Tan 

机构地区：[1]Academy of Food Interdisciplinary Science,School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China [2]Institute of Cancer Stem Cell,Cancer Center,Dalian Medical University,Dalian 116044,China [3]National Engineering Research Center of Seafood,Dalian Polytechnic University,Dalian 116034,China [4]Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China

出　　处：《Food Science and Human Wellness》2024年第2期688-697,共10页食品科学与人类健康（英文）

基　　金：supported by Dalian Youth Science and Technology Star Project(2020RQ121);the National Science Fund for Distinguished Young Scholars of China(31925031);Doctoral Scientific Research Foundation of Liaoning Province(2020-BS-211);Liaoning Province Education Administration(J2020101)。

摘　　要：Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend longevity.The natural flavonol fisetin has been shown to antagonize senescence in vitro and increases longevity in vivo,but has poor water solubility and limited bioavailability.In this study,a food-grade and senescent cell-targeted delivery system for fisetin was developed based on whey protein isolate-galactooligosaccharides(WPI-GOS)Maillard conjugate,which could recognize senescence associatedβ-galactosidase in senescent cells.The fisetin nanoparticles possessed a high encapsulation efficiency,excellent dispersibility in water,good storage stability and well biocompatibility.Moreover,they could effectively accumulate and retain in senescent cells with excellent senescent cell-targeting efficacy,and inhibit the oxidative stress-induced cellular senescence in vitro.Thus,this novel nanoparticle system based on WPI-GOS Maillard conjugate showed promise to deliver hydrophobic bioactive ingredients like fisetin to senescent cells to improve their bioavailability and anti-senescence effect.

关 键 词：FISETIN Nanoparticle Cellular senescence Targeted delivery 

分 类 号：TS201.2[轻工技术与工程—食品科学]