RADIOSENSITIZER

作品数：27被引量：75H指数：4
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Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor
《Chinese Chemical Letters》2025年第2期234-241,共8页Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu 
funded by a grant from Technology Project of Science and technology department of Sichuan province(No.2018SZ0021)。
It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need ...
关键词：FISETIN Polymetric micelles Radiotherapy RADIOSENSITIZER Platelet-derived growth factor receptor-β 
A review of therapeutic agents for breast cancer with potentially radiosensitizing properties
《Radiation Medicine and Protection》2024年第2期75-82,共8页Zhongwei Zhang David Lim Zhihui Feng 
National Natural Science Foundation of China,China(No.82173460,82373518).
Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death.Radiotherapy for breast cancer is readily accepted and widely used in clinical practice.Potential...
关键词：Breast cancer RADIOTHERAPY RADIOSENSITIZER Therapeutic agents 
Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer被引量：1
《Bioactive Materials》2023年第12期200-213,共14页Yanhong Duo Zide Chen Zihuang Li Xing Li Yaoqiang Yao Tianzhao Xu Ge Gao Guanghong Luo 
the National Natural Science Foundation of China(82102904);the Science,Technology&Innovation Commission of Shenzhen Municipality(Nos.JCYJ20190807144605514,JCYJ20210324113405014,JCYJ20210324113810029 and JCYJ20190808154213097);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110534);Medical Science and Technology Foundation of Guangdong Province(No.A2022122);Scientific research project of Guangdong Bureau of traditional Chinese Medicine(20231002);Science and Technology Program of Guangzhou(No.2023A04J0535);Start-up Funding for the National Natural Project of Guangdong Provincial People’s Hospital in 2022(No.8220070617).
Aggregation-Induced Emission luminogen(AIEgen)possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety....
关键词：Aggregation-induced emission VNP20009 RADIOTHERAPY Immunogenic cell death IMMUNOTHERAPY Abscopal effect 
Hexyl-pentynoic acid serves as a novel radiosensitizer for breast cancer by inhibiting UCHL3-dependent Rad51 deubiquitination
《Radiation Medicine and Protection》2023年第4期204-213,共10页Zuchao Cai David Lim Beidi Jia Guochao Liu Wenwen Ding Zhendong Wang Zhujun Tian Junxuan Peng Fengmei Zhang Chao Dong Zhihui Feng 
supported by grants from Zhejiang Provincial Natural Science Foundation of China(LQ23H14003);National Natural Science Foundation of China(81472800,82173460);Department of Science and Technology of Shandong Province(2019GSF108083);Zhejiang Provincial Postdoctoral Scientific Research Project Funding(ZJ2022076),China.
Objective:To investigate the effects and underlying mechanism of 2-hexyl-4-pentynoic acid(HPTA),a derivative of valproic acid(VPA),on radiotherapy in breast cancer.Methods:MCF7 cells and 7,12-dimethylbenz-[α]-anthrac...
关键词：2-hexyl-4-pentynoic acid RADIOSENSITIZATION UCHL3 RAD51 Homologous recombination DEUBIQUITINATION 
High-dimensional zinc porphyrin nanoframeworks as efficient radiosensitizers for cervical cancer
《Chinese Chemical Letters》2023年第7期182-185,共4页Fei Cai Kun Ye Mingkai Chen Yuan Tian Peicong Chen Hao Lin Tianfeng Chen Li Ma 
supported by National Natural Science Foundation of China (Nos. 21877049, 22177038, 32171296);Guangdong Natural Science Foundation (Nos. 2020B1515120043, 2022A1515012235);Major Program for Tackling Key Problems of Industrial Technology in Guangzhou (Nos. 201902020013);Guangdong Pearl River Talent Program (No. 2017GC010354);Innovation Team Project in Guangdong Colleges and Universities (Nos. 2019KCXTD008, 2019KTSCX012)。
Radiotherapy is widely used clinically, but the toxic and side effects of nonselective killing of high-energy radiation limit its application. Finding biocompatible materials to assemble radiotherapy sensitizers and s...
关键词：Zinc porphyrin frameworks Nanoframeworks RADIOSENSITIZER APOPTOSIS 
Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy被引量：3
《Bioactive Materials》2022年第11期276-288,共13页Rong Chai Luodan Yu Caihong Dong Yipengchen Yin Sheng Wang Yu Chen Qin Zhang 
The authors greatly acknowledge the financial support from the National Natural Science Foundation of China(Grant Nos.81703021,81772604);Basic Research Program of Shanghai Municipal Government(Grant No.21JC1406002);Shanghai Science and Technology Program(Grant No.21010500100);Youth Program of National Natural Science Foundation of China(Grant No.51902334);Shanghai Pujiang Program(2020PJD56).
The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires the large X-ray doses for tumor treatment but induces the serious side effects. Herein, a ...
关键词：CYANOBACTERIA PHOTOSYNTHESIS 2D bismuthene RADIOSENSITIZATION Hypoxia alleviation 
ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines
《Cancer Biology & Medicine》2022年第7期983-994,共12页Yi Xie Bing Wang Liqing Du Yan Wang Chang Xu Hong Zhang Kaixue Wen Qiang Liu Takanori Katsube 
supported by grants from the National Key R&D Program of China(Grant Nos.2018YFE0205100 and 2018YFE0205101);the National Natural Science Foundation of China(Grant Nos.11605260 and 31670859);the Key Research and Development Projects of Shanxi Province(Grant No.201903D321115);the Science and Technology Talent Project in Lanzhou(Grant No.2018-RC-66);the Science and Technology Project of Chengguan District of Lanzhou(Grant No.2020RCCX0038);the CAMS Innovation Fund for Medical Science(Grant No.2017-I2M-1-016);the Ministry of Education,Culture,Sports,and Science Technology Grantin-Aid for Scientific Research on Innovative Areas with Heavy Ions at NIRS-HIMAC,Japan[Grant Nos.JP15K21745,15H05944,and 15H05935(Living in Space),and Research Project Grant(14J313)].
Objective:The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins,ANTP-SMACN7,on lung cancer cells treated with accelerated carbon and F...
关键词：Fe-particle radiation carbon-particle radiation non-small cell lung cancer cells CASPASE RADIOSENSITIZER 
Boosting image-guiding radiation therapy through W_(18)O_(49) nanospheres and the second near-infrared light irradiation被引量：1
《Nano Research》2022年第3期2315-2323,共9页Nannan Zheng Shouhao Zhang Lu Wang Zhilin Qi Qiang Peng Lingrui Jian Yang Bai Yue Feng Jiachen Shen Ranxu Wang Jia Jiao Wanhai Xu Shaoqin Liu 
the National Science Fund for Distinguished Young Scholars(No.51825202,S.Q.L.);the National Natural Science Foundation of China(Nos.21775032(S.Q.L.);U20A20339(N.N.Z.));Heilongjiang Touyan Innovation Team Program(S.Q.L.).
More than 60%of cancer patients receive radiation therapy(RT)during their anticancer treatment.However,there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease da...
关键词：W_(18)O_(49) tumor metastasis RADIOSENSITIZER PHOTOTHERAPY singlet oxygen 
Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles
《Bioactive Materials》2022年第1期74-84,共11页Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.Webster Behrooz Johari Hossein Danafar 
This work was supported by the Deputy of Research of Zanjan University of Medical Sciences(grant no.A-12-430-42,ethical code:IR.ZUMS.REC.1399.129);MB acknowledges the financial support of the Scientific and Technological Research Council of Turkey for Material Characterization(TUBITAK,217Z069).
Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer treatment.For such treatment,nanoparticles can serve as improved carriers of chemother...
关键词：Combination therapy RADIOSENSITIZER Semiconductor Heterojunction RADIOPROTECTOR 
Salivary Gland Tumors: Randomized Study of Adjuvant Chemo-Radiotherapy versus Radiotherapy Alone
《Journal of Cancer Therapy》2021年第10期531-553,共23页Tarek Shouman Azza Niazy Taher Amany Helal Ahmed Charaf 
Objective: Concurrent chemoradiation value of the resected salivary tumor adjuvant context against regular radiation therapy alone.
关键词：Salivary gland Tumors CHEMORADIATION RADIOSENSITIZER CISPLATIN Adenoid Cystic Tumors MUCOEPIDERMOID 
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