Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer  

作　　者：Yanhong Duo Zide Chen Zihuang Li Xing Li Yaoqiang Yao Tianzhao Xu Ge Gao Guanghong Luo 

机构地区：[1]Department of Radiation Oncology,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,SouthernUniversity of Science and Technology),Shenzhen,518020,Guangdong,China [2]School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China [3]Department of Microbiology,Tumor and Cell Biology(MTC),Karolinska Institutet,Stockholm,17177,Sweden [4]Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen,518172,Guangdong,China [5]Department of Interventional Radiology,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,510080,Guangdong,China [6]Department of Laboratory Medicine,The Third Xiangya Hospital,Central South University,Changsha,410013,China

出　　处：《Bioactive Materials》2023年第12期200-213,共14页生物活性材料（英文）

基　　金：the National Natural Science Foundation of China(82102904);the Science,Technology&Innovation Commission of Shenzhen Municipality(Nos.JCYJ20190807144605514,JCYJ20210324113405014,JCYJ20210324113810029 and JCYJ20190808154213097);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110534);Medical Science and Technology Foundation of Guangdong Province(No.A2022122);Scientific research project of Guangdong Bureau of traditional Chinese Medicine(20231002);Science and Technology Program of Guangzhou(No.2023A04J0535);Start-up Funding for the National Natural Project of Guangdong Provincial People’s Hospital in 2022(No.8220070617).

摘　　要：Aggregation-Induced Emission luminogen(AIEgen)possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety.Bacteria as a natural carrier have demonstrated great advantages in tumor targeted delivery and penetration to tumor.Herein,we construct a delivery platform that Salmonella VNP20009 act as an activated bacteria vector loaded the as-prepared novel AIEgen(TBTP-Au,VNP@TBTP-Au),which showed excellent radioimmunotherapy.VNP@TBTP-Au could target and retain AIEgen at the tumor site and deliver it into tumor cells specially,upon X-ray irradiation,much ROS was generated to induce immunogenic cell death via cGAS-STING signaling pathway to evoke immune response,thus achieving efficient radioimmunotherapy of the primary tumor with good biosafety.More importantly,the radioimmunotherapy with VNP@TBTP-Au formatted good abscopal effect that was able to suppress the growth of distant tumor.Our strategy pioneer a novel and simple strategy for the organic combination of bacteria and imaging-guided radiotherapy,and also pave the foundation for the combination with immunotherapy for better therapeutic effects.

关 键 词：Aggregation-induced emission VNP20009 RADIOTHERAPY Immunogenic cell death IMMUNOTHERAPY Abscopal effect 

分 类 号：R730.51[医药卫生—肿瘤]