Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles  

作　　者：Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.Webster Behrooz Johari Hossein Danafar 

机构地区：[1]Zanjan Pharmaceutical Biotechnology Research Center,Zanjan University of Medical Sciences,Zanjan,Iran [2]Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems,Drohobych,Ukraine,Baku,Azerbaijan [3]Department of Radiology,School of Paramedical Sciences,Zanjan University of Medical Sciences,Zanjan,45139-56184,Iran [4]Hacettepe University,Department of Chemistry,Beytepe,Ankara,06800,Turkey [5]Department of Medical Biotechnology,School of Medicine,Zanjan University of Medical Sciences,Zanjan,45139-56184,Iran [6]Department of Pharmaceutical Nanotechnology,School of Pharmacy,Zanjan University of Medical Sciences,Zanjan,Iran [7]Department of Surface Engineering,The John Paul II Catholic University of Lublin,20-950,Lublin,Poland [8]Drohobych Ivan Franko State Pedagogical University,82100,Drohobych,Ukraine [9]Department of Chemical Engineering,Northeastern University,360 Huntington Avenue,Boston,MA,02115,United States

出　　处：《Bioactive Materials》2022年第1期74-84,共11页生物活性材料（英文）

基　　金：This work was supported by the Deputy of Research of Zanjan University of Medical Sciences(grant no.A-12-430-42,ethical code:IR.ZUMS.REC.1399.129);MB acknowledges the financial support of the Scientific and Technological Research Council of Turkey for Material Characterization(TUBITAK,217Z069).

摘　　要：Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer treatment.For such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized radiotherapy.Herein,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray irradiation.Methotrexate(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release behavior.The designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal cells.Impressively,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications.

关 键 词：Combination therapy RADIOSENSITIZER Semiconductor Heterojunction RADIOPROTECTOR 

分 类 号：R73[医药卫生—肿瘤]