Targeting MUC1 with fisetin in oral squamous cell carcinoma  

作　　者：Qian Wang Hongyan Zhang Shuzhen Xiang Lan Zhang Jiajia Fan Zengyan Xu Fengfei Zhao Minda Liu Yanshu Li Wei Dai 

机构地区：[1]Department of Oral Maxillofacial-Head and Neck Surgery,School of Stomatology,China Medical University,Oral Diseases Laboratory of Liaoning,Shenyang,Liaoning 110000,China [2]Department of Cell Biology,Key Laboratory of Cell Biology,Ministry of Public Health,China Medical University,Shenyang,Liaoning 110122,China [3]Key Laboratory of Medical Cell Biology,Ministry of Education,China Medical University,Shenyang,Liaoning 110122,China

出　　处：《Genes & Diseases》2025年第3期46-49,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.81902701 to Y.L.,82103649 to H.Z.);the Natural Science Foundation of Liaoning Province,China(No.20180530037 to Y.L.,2022-MS-183 to W.D.).

摘　　要：Poor prognosis is associated with oral squamous cell carcinoma(OSCC),an aggressive form of malignant tumor.1 Developing effective targeted therapies against OSCC is anticipated to have significant clinical implications.Fisetin(3,30,40,7-tetrahydroxyflavone),a natural flavonoid,the most common phytochemical found in a variety of fruits and vegetables,may bring several therapeutic potential benefits to people.2 Investigating the pharmacological impact of natural flavonoid fisetin on the management of OSCC was the aim of the current investigation.By focusing on the tumor-associated antigen MUC1(mucin 1),fisetin prevents OSCC cells from transforming malignant.This study aims to provide new diagnostic indicators and therapeutic targets for the diagnosis and treatment of OSCC by exploring the role and mechanism of fisetin in OSCC.

关 键 词：natural flavonoid tumor associated antigen therapeutic potential MUC FISETIN oral squamous cell carcinoma diagnostic indicators developing effective targeted therapies 

分 类 号：R739.8[医药卫生—肿瘤]