Enhancing tumor radiotherapy sensitivity through metal nanomaterials:A comprehensive review  

作　　者：Susu Xiao Xiaoxiao Wang Bo Chen Min Mu Bo Han Nianyong Chen Gang Guo 

机构地区：[1]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,Department of Radiation Oncology and Department of Head and Neck Oncology,West China Hospital,Sichuan University,Chengdu,Sichuan,China [2]Department of Pediatric Dentistry,West China Hospital of Stomatology,Chengdu,Sichuan,China [3]Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education,Shihezi University College of Pharmacy,Shihezi,Xinjiang,China

出　　处：《Malignancy Spectrum》2024年第4期243-262,共20页肿瘤学全景(英文)

基　　金：supported by the Science and Technology Plan Project of Bingtuan(2023AB047);the National Natural Sciences Foundation of China(31971308,82102767,and U1903211);the National S&T Major Project(2019ZX09301-147);the Natural Science Foundation of Sichuan Province(2023NSFSC1866);Sichuan Science and Technology Program(2022YFS0007);Luzhou Science and Technology Plan(2018CDLZ-10).

摘　　要：Radiotherapy(RT)plays a crucial role in tumor treatment and is an indispensable therapeutic approach.However,ionizing radiation often damages the normal tissues surrounding the tumor.Therefore,there is an urgent need for effective methods to improve the precision of RT.Nanotechnology has shown potential in enhancing the efficacy and safety of tumor RT.With the continuous development of multifunctional nanomaterials,various nanomaterials have been designed and investigated as radiation enhancers.Metallic nanomaterials are considered as promising radiosensitizers with potential for clinical translation.High atomic number(high-Z)metal nanoparticles(NPs),such as gold and bismuth,have garnered increasing attention for their ability to enhance the radiation effect,as they can potentially improve RT outcomes.New nanomedicine strategies may help to advance RT.This paper concisely explains the radiation enhancement mechanisms of high-Z metal NPs.It also enumerates several commonly studied high-Z metallic nanomaterials used in tumor RT and discusses their potential clinical applications.

关 键 词：RADIOTHERAPY NANOMATERIALS RADIOSENSITIZATION high-Z metal TUMOR 

分 类 号：R730.55[医药卫生—肿瘤] TG14[医药卫生—临床医学] TB383.1[一般工业技术—材料科学与工程]