Targeting the organelle for radiosensitization in cancer radiotherapy  

作　　者：Xiaoyan Sun Linjie Wu Lina Du Wenhong Xu Min Han 

机构地区：[1]Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China [3]Department of Radiation Oncology,Key Laboratory of Cancer Prevention and Intervention,The Second Afliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310058,China [4]Hangzhou Institute of Innovative Medicine,Zhejiang University,Hangzhou 310058,China [5]Jinhua Institute of Zhejiang University,Jinhua 321299,China [6]National Key Laboratory of Advanced Drug Delivery and Release Systems,Zhejiang University,Hangzhou 310058,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第2期52-71,共20页亚洲药物制剂科学（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82172186);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160030);the National Natural Science Foundation of China(No.82373206,No.82073332);the National Key Research and Development Program of China(No.2022YFE0107800).

摘　　要：Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.

关 键 词：Cancer radiotherapy Organelle-target RADIOSENSITIZATION Boron neutron capture therapy NANOMEDICINES 

分 类 号：R943[医药卫生—药剂学]