Advances of radiotherapy combined with targeted therapy for nasopharyngeal carcinoma  

作　　者：Xiaoyan Xu Hengzhao Zhuang Yijun Xu Zhongxu Xing Yang Jiao Lili Wang 

机构地区：[1]Department of Radiation Oncology,First Affiliated Hospital of Soochow University,Suzhou 21500,China [2]School of Radiation Medicine and Protection,Medical College of Soochow University,Suzhou 215000,China

出　　处：《Radiation Medicine and Protection》2023年第4期197-203,共7页放射医学与防护（英文）

基　　金：supported by the National Natural Science Foundation of China(82073476);the National Key R&D Program of China(2022YFC2503700,2022YFC2503703);Jiangsu Provincial Medical Key Discipline(ZDXK202235);Innovation Research Project of Medical and Industrial Cooperation in Suzhou(SLJ2021005),China.

摘　　要：Nasopharyngeal carcinoma is insidious at onset,prone to lymph node metastasis,and has a high rate of locally advanced disease at initial diagnosis.Radiotherapy combined with chemotherapy is the main treatment for locally advanced nasopharyngeal carcinoma,but local recurrence and distant metastasis often lead to treatment failure,of which radioresistance caused by radiotherapy may be one of the reasons.Targeted therapy can selectively inhibit tumor proliferation and metastasis,and patients can achieve long-term survival benefits with low toxic and side effects.Targeted therapy involves a variety of tumor mechanisms,in which combination with radiotherapy may improve radioresistance and the efficacy of radiotherapy.In this review,the advantages and research progress of targeted therapy combined with radiotherapy for nasopharyngeal carcinoma were discussed.

关 键 词：Nasopharyngeal carcinoma RADIOTHERAPY Targeted therapy RADIORESISTANCE RADIOSENSITIVITY ANGIOGENESIS 

分 类 号：R739.62[医药卫生—肿瘤]