EPIGENOME

作品数：49被引量：129H指数：6
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相关领域：生物学医药卫生更多>>
相关作者：郗乔然宋高远杨代常更多>>
相关机构：武汉大学清华大学更多>>
相关期刊：《Journal of Biomedical Science and Engineering》《Science Bulletin》《Current Medical Science》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家高技术研究发展计划福建省自然科学基金更多>>
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Single-cell omics: experimental workflow, data analyses and applications被引量：1
《Science China(Life Sciences)》2025年第1期5-102,共98页Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi 
supported by the National Natural Science Foundation of China(32130020,32025009,82030099,30700397,31970638,61572361,81973701,U23A20513,32222026,82373446);the National Key Research and Development Program of China(2021YFF1201200,2021YFF1200900,2022YFA1106000);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);the Fundamental Research Funds for the Central Universities(20002150110,22120230292);Beihang University&Capital Medical University Plan(BHME-201904);the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(XTCX201809);the Cooperative Research Fund of the Affiliated Wuhu Hospital of East China Normal University(40500-20104-222400);the Fundamental Research Funds for the Central Universities(226-2024-00001);the Shanghai Municipal Science and Technology Commission“Science and Technology Innovation Action Plan”technical standard project(21DZ2201700);the Shanghai Municipal Science and Technology Commission“Science and Technology Innovation Action Plan”natural science foundation project(23ZR1435800);the Shanghai Natural Science Foundation Program(17ZR1449400);the Shanghai Artificial Intelligence Technology Standard Project(19DZ2200900);the Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE,ECNU,Key Laboratory of MEA,Ministry of Education,ECNU.
Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features.Our exploration of how the genomes orchestrate the formation and maintenance of each cell,and co...
关键词：single-cell sequencing genome EPIGENOME PROTEOMICS metabolomics multimodal spatial transcriptomics CRISPR screening 
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
《Military Medical Research》2024年第6期863-886,共24页Dian Xiong Lu Zhang Zhi-Jun Sun 
supported by the National Natural Science Foundation of China(82273202,82370948,82072996,82170941);the Fundamental Research Funds for the Central Universities(2042022dx0003);the Hubei Province International Science and Technology Cooperation Project(2021EHB027);the National Key Research and Development Program(2022YFC2504200).
Cancer immunotherapy using immune-checkpoint inhibitors(ICIs)has revolutionized the field of cancer treatment;however,ICI efficacy is constrained by progressive dysfunction of CD8+tumor-infiltrating lymphocytes(TILs),...
关键词：Epigenetic therapy Immune checkpoint blockade Combination therapy T cell exhaustion Immune macroenvironment Spatial immune contexture Immunometabolism Cancer microbiome 
Re-searching nasopharyngeal carcinoma被引量：1
《广西医科大学学报》2024年第9期1227-1236,共10页Ingemar Ernberg ZHENG Shixing ZHOU Xiaoying 
Nasopharyngeal carcinoma(NPC)has been a focus of medical research for more than 100 years,with significant interest emerging over the last 58 years following the identification of the link between the disease and Epst...
关键词：nasopharyngeal carcinoma Epstein-Barr virus risk factors EPIGENOME tumor microenvironment 
Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses被引量：4
《Molecular Plant》2024年第3期438-459,共22页Xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang Xiaoyu Zhang Xiaomin Bie Lixuan Gui Zhongxu Chen Yiliang Ding Long Mao Xueyong Zhang Fei Lu Xiansheng Zhang Cristobal Uauyo Xiangdong Fu Jun Xiao 
supported by the National Natural Science Foundation of China(31921005);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24010204);the National Key Research and Development Program of China(2021YFD1201500);the Major Basic Research Program of Shandong Natural Science Foundation of China(ZR2019ZD15).
The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding programs.In this study,we used a multi-omic approach to analyze the transcripto...
关键词：wheat spike development EPIGENOME TRN TaMYB30-A1 breeding selection 
Multimodal Omics Approaches to Aging and Age‑Related Diseases被引量：1
《Phenomics》2024年第1期56-71,共16页Qianzhao Ji Xiaoyu Jiang Minxian Wang Zijuan Xin Weiqi Zhang Jing Qu Guang‑Hui Liu 
the National Key Research and Development Program of China(2020YFA0804000,2022YFA1103700,2020YFA0112200,2021YFF1201000);the National Natural Science Foundation of China(81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation(Z190019);Youth Innovation Promotion Association of CAS(E1CAZW0401);the Informatization Plan of Chinese Academy of Sciences(CASWX2021SF-0301,CAS-WX2022SDC-XK14,CAS-WX2021SF-0101);New Cornerstone Science Foundation through the XPLORER PRIZE(2021-1045).
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders.An increasing body of experimental evidence shows that aging is a complex biological proce...
关键词：Multimodal omics approaches AGING GENOME EPIGENOME 
Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment被引量：2
《Journal of Genetics and Genomics》2024年第2期159-183,共25页Yuxi Chen Xiao Luo Rui Kang Kaixin Cui Jianping Ou Xiya Zhang Puping Liang 
supported by the National Natural Science Foundation(32001063 and 82201769);the Guangdong Special Support Program(2019BT02Y276);the Guangdong Basic and Applied Basic Research Foundation(2021A1515010759 and 2023A1515010176);the grant from MOE Key Laboratory of Gene Function and Regulation,the Guangzhou Science and Technology Planning Project(202201020411 and 2023A04J1952);the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(23ptpy59).
Osteoarthritis(OA)is one of the most common degenerative joint diseases worldwide,causing pain,disability,and decreased quality of life.The balance between regeneration and inflammation-induced degradation results in ...
关键词：OSTEOARTHRITIS Genome editing Epigenone editing RNA editing 
Hypercompact CRISPR–Cas12j2 (CasF) enables genome editing, gene activation, and epigenome editing in plants被引量：5
《Plant Communications》2022年第6期131-134,共4页Shishi Liu Simon Sretenovic Tingting Fan Yanhao Cheng Gen Li Aileen Qi Xu Tang Yang Xu Weijun Guo Zhaohui Zhong Yao He Yanling Liang Qinqin Han Xuelian Zheng Xiaofeng Gu Yiping Qi Yong Zhang 
supported by the National Key Research and Development Program of China(award no.NK2022010204)to Y.Z.;the National Natural Science Foundation of China(award nos.32270433,32101205,32072045,and 31960423)to X.T.,X.Z.,and Y.Z.;the Sichuan Science and Technology Program(award no.2021JDRC0032)to Y.Z.;the Technology Innovation and Application Development Program of Chongqing(award no.CSTC2021JSCX-CYLHX0001)to X.T.and Y.Z.;supported by the National Science Foundation Plant Genome Research Program grant(award nos.IOS-1758745 and IOS2029889);USDA-AFRI Agricultural Innovations Through Gene Editing Program(award no.2021-67013-34554)to Y.Q.S.S.is a fellow of the Foundation for Food and Agriculture Research.
CRISPR-Cas9,-Cas12a,-Cas12b,and-Cas13 have been harnessed for genome engineering in human and plant cells(Liu et al.,2022).However,the large size of these Cas proteins(e.g.190 kDa for SpCas9)makes them difficult to de...
关键词：CRISPR ACTIVATION system 
A combinatorial indexing strategy for low-cost epigenomic profiling of plant single cells被引量：2
《Plant Communications》2022年第4期72-82,共11页Xiaoyu Tu Alexandre P.Marand Robert J.Schmitz Silin Zhong 
funded with support from the NSFC for Young Scientists(32100438);the China Postdoctoral Science Foundation(2020M672858 and 2021T140677)(to X.T.);Hong Kong GRF-14104119,GRF-14109420;and AoE/M-403/16;funding from the State Key Laboratory of Agrobiotechnology(to S.Z.);the NSF(IOS-1856627);the UGA Office of Research(to R.J.S.);an NSF postdoctoral fellowship in biology(DBI-1905869 to A.P.M.).
Understanding how cis-regulatory elements facilitate gene expression is a key question in biology.Recent advances in single-cell genomics have led to the discovery of cell-specific chromatin landscapes that underlie t...
关键词：combinatorial indexing single-cell ATAC-seq EPIGENOME 
Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective被引量：1
《Neural Regeneration Research》2022年第8期1745-1747,共3页Fabio Coppedè 
Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA sequence,and include DNA methylation and hydroxymethylation,post-translational modifications of histon...
关键词：DISEASES COLLECTIVE REMOVE 
Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes被引量：2
《Journal of Genetics and Genomics》2022年第4期279-286,共8页Linpeng Li Keshi Chen Yi Wu Ge Xiang Xingguo Liu 
financially supported by the National Key Research and Development Program of China (2017YFA0106300);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030505);the National Natural Science Foundation projects of China (2017YFA0102900, 2019YFA09004500, 2017YFC1001602, 2016YFA0100300, 2018YFA0107100);the National Natural Science Foundation projects of China (92157202, 32025010, 31801168, 31900614, 31970709, 81901275, 32070729, 32100619, 32170747);the Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SMC001);International Cooperation Program (154144KYSB20200006);Guangdong Province Science and Technology Program (2020B1212060052, 2018A030313825, 2018GZR110103002, 2020A1515011200, 2020A1515010919, 2020A1515011410, 2021A1515012513);Guangzhou Science and Technology Program (201807010067, 202002030277, 202102021250, 202102020827, 202102080066), Open Research Program of Key Laboratory of Regenerative Biology, CAS (KLRB201907, KLRB202014);CAS Youth Innovation Promotion Association (to Y. W. and K. C.)
Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years.However,the mechanisms of multilevel regulation of cell fate determination r...
关键词：Cell biological processes CHROMATIN EPIGENOME METABOLOME Signaling cascade 
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