Multimodal Omics Approaches to Aging and Age‑Related Diseases  

作　　者：Qianzhao Ji Xiaoyu Jiang Minxian Wang Zijuan Xin Weiqi Zhang Jing Qu Guang‑Hui Liu 

机构地区：[1]State Key Laboratory of Membrane Biology,Instituteof Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]State Key Laboratory of Stem Cell and ReproductiveBiology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [3]Key Laboratory of Organ Regeneration and Reconstruction,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [4]CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academyof Sciences and China National Center for Bioinformation,Beijing 100101,China [5]University of Chinese Academy of Sciences,Beijing 100049,China [6]Institute for Stem Cell and Regeneration,Chinese Academyof Sciences,Beijing 100101,China [7]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China [8]School of Future Technology,University of ChineseAcademy of Sciences,Beijing 100190,China [9]Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for GeriatricDisorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China [10]Aging Translational Medicine Center,International Centerfor Aging and Cancer,Xuanwu Hospital,Capital MedicalUniversity,Beijing 100053,China

出　　处：《Phenomics》2024年第1期56-71,共16页表型组学（英文）

基　　金：the National Key Research and Development Program of China(2020YFA0804000,2022YFA1103700,2020YFA0112200,2021YFF1201000);the National Natural Science Foundation of China(81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation(Z190019);Youth Innovation Promotion Association of CAS(E1CAZW0401);the Informatization Plan of Chinese Academy of Sciences(CASWX2021SF-0301,CAS-WX2022SDC-XK14,CAS-WX2021SF-0101);New Cornerstone Science Foundation through the XPLORER PRIZE(2021-1045).

摘　　要：Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders.An increasing body of experimental evidence shows that aging is a complex biological process coordinately regulated by multiple factors at diferent molecular layers.Thus,it is difcult to delineate the overall systematic aging changes based on single-layer data.Instead,multimodal omics approaches,in which data are acquired and analyzed using complementary omics technologies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise molecular regulatory mechanisms that trigger aging.In recent years,multimodal omics sequencing technologies that can reveal complex regulatory networks and specifc phenotypic changes have been developed and widely applied to decode aging and age-related diseases.This review summarizes the classifcation and progress of multimodal omics approaches,as well as the rapidly growing number of articles reporting on their application in the feld of aging research,and outlines new developments in the clinical treatment of age-related diseases based on omics technologies.

关 键 词：Multimodal omics approaches AGING GENOME EPIGENOME 

分 类 号：R339.38[医药卫生—人体生理学]