Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination  

作　　者：Rong Hu Xinpeng Dun Lolita Singh Matthew C.Banton 

机构地区：[1]School of Traditional Chinese Medicine,Department of Traditional Chinese Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China [2]The Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China [3]Faculty of Health,University of Plymouth,Plymouth,UK

出　　处：《Neural Regeneration Research》2024年第7期1575-1583,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82104795 (to RH)。

摘　　要：Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea r.Here,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann cells.Furthermore,using Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were Runx2-dependent.Changes observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block in macrophage clearance in the late stage of regeneration.Taken together,our findings indicate that Runx2 is a key regulator of Schwann cell plasticity,and therefore peripheral nerve repair.Thus,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury.

关 键 词：macrophage clearance MIGRATION peripheral nerve injury regeneration re-myelination RUNX2 Schwann cells 

分 类 号：R741[医药卫生—神经病学与精神病学]