supported by National Key Research and Development Program of China(No.2021YFB3800800 to D.C.and L.T);the National Natural Science Foundation of China(No.82030067,82250710174,82161160342,82060406,82360429 and 82172397 to D.C.and L.T.and Y.C.);the Hong Kong RGC(China)(No.HKU-17101821 to W.W.L and D.C.);Shenzhen Science and Technology Program(Guangdong,China)(No.JSGGKQTD20210831174330015 to H.P.and D.C.);Natural Science Foundation of Guangxi(No.2022JJA141126 to Y.C.).
Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved ...