Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders  

作　　者：Ariel Nir Sade Gal Wiener Boaz Barak 

机构地区：[1]Sagol School of Neuroscience,Tel Aviv University,Tel Aviv,Israel [2]School of Psychological Sciences,Tel Aviv University,Tel Aviv,Israe

出　　处：《Neural Regeneration Research》2026年第2期659-660,共2页中国神经再生研究(英文版)

摘　　要：Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.

关 键 词：neurodevelopmental disorders ndds rokach white matter developing brain MYELINATION neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina 

分 类 号：R741[医药卫生—神经病学与精神病学]