DEMYELINATION

作品数：86被引量：255H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：孙文婧更多>>
相关机构：普渡大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Chinese Journal of Integrative Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划重庆市自然科学基金湖北省自然科学基金更多>>
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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics
《Neural Regeneration Research》2025年第11期3179-3192,共14页Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans 
supported by KU Leuven Internal Funding(C3/21/012);the Research Foundation Flanders(FWO G092222N)(to LM)。
Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and oligodendrocytes.However,recent studies employing single-cell RNA sequencing techniques have ...
关键词：animal models DEMYELINATION fish MAMMALS multiple sclerosis MYELIN neurodegeneration OLIGODENDROCYTES oligodendroglial lineage REMYELINATION 
EZH2-dependent myelination following sciatic nerve injury
《Neural Regeneration Research》2025年第8期2382-2394,共13页Hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue 
financially supported by the National Natural Science Foundation of China,Nos.82172104(to CX),81873767(to HZ);a grant from Jiangsu Provincial Research Hospital,Nos.YJXYY202204(to HZ),YJXYY202204-ZD04(to HZ);a grant from Jiangsu Provincial Key Medical Center;Jiangsu Provincial Medical Innovation Center,No.CXZX202212;Jiangsu Provincial Medical Key Discipline,No.ZDXK202240;the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Technology Project of Nantong,No.MS22022008(to HZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.SJCX21_1457(to WW)。
Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury.Notably,the gene regulatory network of regenerated myelin differs from that ...
关键词：DEMYELINATION EZH2 MYELINATION peripheral nerve injury PRC2 REMYELINATION Schwann cells sciatic nerve crush sciatic nerve transection 
Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination
《World Journal of Psychiatry》2025年第3期288-301,共14页Chun-Yu Li Shu-Jun Zhang Jia-Lu Xu Yan Yang Zhi-Xuan Zeng De-Lin Ma 
Supported by the National Natural Science Foundation of China,No.82300894.
BACKGROUND Diabetes is associated with increased cognitive decline and dementia due to the loss of myelinated nerve fiber function,which is linked to oligodendrocyte dysfunction.The voltage-gated proton channel 1(Hv1)...
关键词：Diabetes Cognitive dysfunction Voltage-gated proton channel 1 Neuroinflammation Myelin regeneration 
Olig2^(+) single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1108-1114,共7页Deqing PENG Ruijie LU Leyao LÜ Qing YAO Kaichuang YANG Yunfeng XU Xiaoming FENG Ruolang PAN Yuyuan MA 
supported by the Zhejiang Provincial Nat ural Science Foundation of China(Nos.LQ21H090016 and LTGY23H090016)。
Oligodendrocytes are the myelinating cells of the central nervous system.Brain injury and neurodegenerative disease often lead to oligodendrocyte death and subsequent demyelination-related pathological changes,resulti...
关键词：MYELIN Olig2^(+) 
GPR34 senses demyelination to promote neuroinflammation and pathologies被引量：1
《Cellular & Molecular Immunology》2024年第10期1131-1144,共14页Bolong Lin Yubo Zhou Zonghui Huang Ming Ma Minghui Qi Zhongjun Jiang Guoyang Li Yueli Xu Jiaxian Yan Di Wang Xiaqiong Wang Wei Jiang Rongbin Zhou 
supported by the National Key Research and Development Program of China(grant number 2020YFA0509101);the National Natural Science Foundation of China(grant numbers 81821001,82130107,U20A20359);the CAS Project for Young Scientists in Basic Research(YSBR-074).
Sterile neuroinflammation is a major driver of multiple neurological diseases.Myelin debris can act as an inflammatory stimulus to promote inflammation and pathologies,but the mechanism is poorly understood.Here,we sh...
关键词：NEUROINFLAMMATION GPCRS MICROGLIA 
Overview of emerging therapies for demyelinating diseases
《World Journal of Clinical Cases》2024年第30期6361-6373,共13页Robert Medina Ann-Marie Derias Maria Lakdawala Skye Speakman Brandon Lucke-Wold 
Robert Medina 0009-0004-1811-6105;Brandon Lucke-Wold,RCID number:0000-0001-6577-4080.
This paper provides an overview of autoimmune disorders of the central nervous system,specifically those caused by demyelination.We explore new research regarding potential therapeutic interventions,particularly those...
关键词：Central nervous system disease AUTOIMMUNE REMYELINATION DEMYELINATION MYELIN OLIGODENDROCYTE Emerging therapies Multiple Sclerosis 
Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice
《Neuroscience Bulletin》2024年第8期1093-1103,共11页Yue Qiu Le Xie Xiaohui Wang Kai Xu Xue Bai Sen Chen Yu Sun 
supported by the National Key Research and Development Program of China(2021YFF0702303);the National Natural Science Foundation of China(82301324,82301323,and 82071058).
GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary deafness.For individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sol...
关键词：Spiral ganglion neurons GJB2 Heminode Hearing loss 
An Investigation on the Application of Online and Offline Hybrid Teaching in Local Anatomy Course of Acupuncture and Moxibustion Specialty
《Journal of Clinical and Nursing Research》2024年第5期219-223,共5页Xiufeng Jin 
The purpose of this paper is to explore the application of online and offline blended teaching in local anatomy courses of acupuncture specialty.It introduces the concept and characteristics of blended teaching mode a...
关键词：Localized demyelination Online and offline Acupuncture specialty Blended teaching 
Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis
《Neural Regeneration Research》2024年第3期578-582,共5页Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry 
supported by the Heart and Stroke Foundation and Ontario Institute of Regenerative Medicine (New Ideas Grant);Canada First Research Excellence Fund(Medicine by Design);the National Sciences and Engineering Research Council;the Jurgen Manchot Foundation;the Christiane and Claudia Hempel Foundation for Clinical Stem Cell Research and the James and Elisabeth Cloppenburg,Peek and Cloppenburg Düsseldorf Stiftung (to PK)
Astrocytes are indispensable for central nervous system development and homeostasis.In response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair response.In this review,...
关键词：ASTROCYTES DEMYELINATION drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis 
Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease被引量：2
《Neural Regeneration Research》2023年第9期1931-1939,共9页Nadège Hertzog Claire Jacob 
supported by the Deutsche Forschungsgemeinshaft (to CJ)。
Schwann cells,the myelinating glia of the peripheral nervous system,wrap axons multiple times to build their myelin sheath.Myelin is of paramount importance for axonal integrity and fast axon potential propagation.How...
关键词：Charcot-Marie-Tooth disease rodent models emerging treatments demyelination and dysmyelination endoplasmic reticulum stress gene therapy MYELIN repair Schwann cells unfolded protein response 
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