Metabolic dysfunction-associated steatotic liver disease,previously known as nonalcoholic fatty liver disease(NAFLD),is becoming increasingly common and is associated with significant morbidity and mortality related t...
supported by the National Natural Science Foundation of China(82471819 and 81871227 to Z.C.);Anhui Provincial Health Research Foundation(AHWJ2023A10120 to Z.C.);Anhui Provincial Natural Science Foundation(2408085J046 to Z.C.);Anhui Provincial Key Research and Development Plan(2022h11020009 to Z.C.);the Fundamental Research Funds for the Central Universities(YD9110002012 to Z.C.).
Dear Editor,Rheumatoid arthritis(RA)is an autoimmune inflammatory disease characterized by symmetric synovial inflammation leading to progressive disability.1 Treatment of RA has been revolutionized by the development...
supported by the Chinese National Key Technology Research and Development Program,Ministry of Science and Technology(2022YFC2504600,2021YFC2501300 and 2019YFC0840603);Beijing Municipal Science&Technology Commission(Z201100005520022,23,25-27);CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-005 and 2022-I2M-1-004);National High Level Hospital Clinical Research Funding(2022-PUMCH-A-107,B-013,C-002,D-009).
Systemic autoimmune diseases(sAIDs)are a spectrum of diseases with multi-organ involvement that share similar clinical manifestations[1].The capacity for diagnosis and treatment of sAIDs is closely associated with the...
Autoimmune enteropathy(AIE)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous atrophy.It has also been observed in adults p...
BACKGROUND Autoimmune phenomena can be used in some patients with nonalcoholic fatty liver disease(NAFLD)in the clinic,but these patients are not autoimmune hepatitis patients.AIM To determine whether autoimmunity is ...
Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine:Studies on the Antimalarial and Drug Resistance Mechanisms of Artemisinin and the Expansion of New Indications (No. ZYYCXTD-C-202002)。
OBJECTIVE: To investigate the efficacy and potential mechanism of Bailing capsule( 百令胶囊, BL) antiautoimmune thyroiditis(AIT). METHODS: Based on the AIT rat model, the effect of BL in alleviating AIT was evaluated ...
Raynaud’s syndrome (RS) is a vasospastic disorder with potential hereditary predisposition and multiple triggering factors. After the exclusion of external stimuli and local disorders, autoimmunity presents a potenti...
supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation):project ID 431549029-SFB 1451(to MS).
Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of life.They are amenable to immunomodulatory treatments,which in many c...
supported by JSPS grants-in-aid for Scientific Research(22J20213 to DO and 19H01026 to KH);the Cooperative Research Program(Joint Usage/Research Center program)of the Institute for Life and Medical Sciences,Kyoto University(KH).Figures 1,3,4,and 5 were created with Biorender.com.
The IL-23 signaling pathway in both innate and adaptive immune cells is vital for orchestrating type 17 immunity,which is marked by the secretion of signature cytokines such as IL-17,IL-22,and GM-CSF.These proinflamma...
supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to U.P.(SFB 1192 A1 and C3);C.F.K.(SFB 1192 A5 and C3,KR 3483/3-1).
In a landmark study recently published in Cell,Berger et al.demonstrated that computationally designed miniproteins could serve as novel,orally available treatment strategies by specifically targeting cytokine signali...