Advances and challenges in diagnosing and managing adult autoimmune enteropathy  

作　　者：Grigorios Christodoulidis Sara E Agko Marina N Kouliou Konstantinos E Koumarelas Dimitris Zacharoulis 

机构地区：[1]Department of General Surgery,University Hospital of Larissa,Larissa 41110,Greece [2]Department of Intensive Care Unit,Asklepios Paulinen Clinic Wiesbaden,Wiesbaden 65197,Germany [3]Department of Emergency Medicine,General Hospital of Larissa,Larissa 41221,Greece [4]Department of Surgery,University Hospital of Larissa,Larissa 41334,Greece

出　　处：《World Journal of Gastroenterology》2025年第2期128-131,共4页世界胃肠病学杂志（英文）

摘　　要：Autoimmune enteropathy(AIE)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous atrophy.It has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac disease.Initial diagnostic criteria for AIE include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe immu-nodeficiency.Refined criteria emphasize characteristic histological findings and exclusion of other causes of villous atrophy.AIE is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial lympho-cytosis.Treatment primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional support.Despite the challenges,understanding AIE’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient outcome.Further research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIE.

关 键 词：Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy 

分 类 号：R575[医药卫生—消化系统]