Olig2^(+) single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model  

作　　者：Deqing PENG Ruijie LU Leyao LÜ Qing YAO Kaichuang YANG Yunfeng XU Xiaoming FENG Ruolang PAN Yuyuan MA 

机构地区：[1]Center for Rehabilitation Medicine,Department of Neurosurgery,Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital,Hangzhou Medical College),Hangzhou 310014,China [2]Second Clinical Medical College,Wenzhou Medical University,Wenzhou 325035,China [3]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China [4]Department of Neurosurgery,the First Hospital of Jiaxing(Affiliated Hospital of Jiaxing University),Jiaxing 314001,China [5]Key Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province,Hangzhou 311122,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1108-1114,共7页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the Zhejiang Provincial Nat ural Science Foundation of China(Nos.LQ21H090016 and LTGY23H090016)。

摘　　要：Oligodendrocytes are the myelinating cells of the central nervous system.Brain injury and neurodegenerative disease often lead to oligodendrocyte death and subsequent demyelination-related pathological changes,resulting in neurological defects and cognitive impairment(Spaas et al.,2021;Zhang J et al.,2022).Multiple sclerosis(MS)is a major demyelinating disease of the central nervous system.

关 键 词：MYELIN Olig2^(+) 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]