Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis  

作　　者：Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry 

机构地区：[1]Department of Neurology,Neuroregeneration laboratory,Medical Faculty,Heinrich-Heine-University,Düsseldorf,Germany [2]Institute of Medical Science,University of Toronto,Toronto,Canada [3]Division of Anatomy,Department of Surgery,University of Toronto,Toronto,Canada

出　　处：《Neural Regeneration Research》2024年第3期578-582,共5页中国神经再生研究（英文版）

基　　金：supported by the Heart and Stroke Foundation and Ontario Institute of Regenerative Medicine (New Ideas Grant);Canada First Research Excellence Fund(Medicine by Design);the National Sciences and Engineering Research Council;the Jurgen Manchot Foundation;the Christiane and Claudia Hempel Foundation for Clinical Stem Cell Research and the James and Elisabeth Cloppenburg,Peek and Cloppenburg Düsseldorf Stiftung (to PK)

摘　　要：Astrocytes are indispensable for central nervous system development and homeostasis.In response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair response.In this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models.We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination.Finally,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.

关 键 词：ASTROCYTES DEMYELINATION drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis 

分 类 号：R744.51[医药卫生—神经病学与精神病学]