FIREproof:Intricacies of microglial biology  

作　　者：Wei Cao 

机构地区：[1]Department of Anesthesiology,Critical Care and Pain Medicine,McGovern Medical School,University of Texas Health Science Center at Houston,Houston,TX,USA

出　　处：《Neural Regeneration Research》2026年第2期663-664,共2页中国神经再生研究(英文版)

基　　金：funded by NIH grants HL154720-03S1,AG057587,AG074283,DK122708-03S1,BrightFocus ADR A20183775,and Brown Foundation 2020 Healthy Aging Initiative(to WC).

摘　　要：Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).

关 键 词：neurological diseases facilitating neurogenesis debris removal central nervous systemincluding NEUROGENESIS MYELINATION synapse pruning brain 

分 类 号：R741[医药卫生—神经病学与精神病学]