Does astrocytic L-lactate enhance cognition through myelination?  

作　　者：Mastura Akter Ying Li 

机构地区：[1]Department of Neuroscience,City University of Hong Kong,Hong Kong Special Administrative Region,China [2]Department of Biomedical Sciences,City University of Hong Kong,Hong Kong Special Administrative Region,China [3]Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong Special Administrative Region,China [4]Centre for Biosystems,Neuroscience,and Nanotechnology,City University of Hong Kong,Hong Kong Special Administrative Region,China

出　　处：《Neural Regeneration Research》2024年第6期1167-1168,共2页中国神经再生研究（英文版）

基　　金：funded by the General Research Fund(GRF)of the Research Grants Council of Hong Kong,China(11103721,11102820,and 11100018);the National Natural Science Foundation of China(NSFC)and RGC Joint Research Scheme(3171101014,N_CityU114/17);the Innovation and Technology Fund Hong Kong,China(CityU 9445909)(all to YL);supported by a grant from City University of Hong Kong Neuroscience Research Infrastructure(9610211);a grant from Center for Biosystems;Neuroscience,and Nanotechnology(9360148)(both to YL)。

摘　　要：Introduction:Astrocytes,the predominant glial cell in the brain,play a vital role in a plethora of central nervous system functions.They are the major storage site of glycogen in the central nervous system.They produce L-lactate by glycogenolysis and glycolysis which is then transported to neurons(Magistretti and Allaman,2018).Multiple evidence using diverse behavioral paradigms,such as fear conditioning,conditioned place avoidance,rat gambling task(RGT),and flavor-place paired associate(PA)learning suggest that L-lactate has a beneficial effect on various aspects of cognition(Wang et al.,2017;Akter et al.,2023b).While the molecular mechanisms underlying the cognitive benefits of L-lactate are still emerging,it is well-established that astrocytic L-lactate can be used as an energy substrate by neurons and can induce N-methyl-D-aspartate receptor-dependent plasticity-driven gene expression during cognition(Magistretti and Allaman,2018).Additionally,recent evidence has revealed more roles of L-lactate which include myelination,neuronal mitochondrial biogenesis,and antioxidant defense(Sanchez-Abarca et al.,2001;Ichihara et al.,2017;Akter et al.,2023a,b).Myelin in the central nervous system is a specialized lipid-rich membrane formed by oligodendrocytes.

关 键 词：MYELIN specialized predominant 

分 类 号：R338[医药卫生—人体生理学]