Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells  

作　　者：Wen Yan Shasha Xiang Jianbo Feng Xuyu Zu 

机构地区：[1]The First Affiliated Hospital,Cancer Research Institute,Hengyang Medical School,University of South China,Hengyang,421001 Hunan,China

出　　处：《Genes & Diseases》2025年第3期319-328,共10页基因与疾病(英文)

基　　金：supported by grants from University of South China Innovation Foundation For Postgraduate(233YXC001);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20230955);the National Natural Science Foundation of China(No.82103171,Jianbo Feng);the Clinical Medical Research“4310”Program of the University of South China(20224310NHYCG07).

摘　　要：Breast cancer (BC) is the most common malignant tumor and the leading cause ofcancer-related deaths among women worldwide. Great progress has been recently achieved incontrolling breast cancer;however, mortality from breast cancer remains a substantial challenge, and new treatment mechanisms are being actively sought. Programmed cell death(PCD) is associated with the progression and treatment of many types of human cancers.PCD can be divided into multiple pathways including autophagy, apoptosis, mitotic catastrophe, necroptosis, ferroptosis, pyroptosis, and anoikis. Ubiquitination is a post-translationalmodification process in which ubiquitin, a 76-amino acid protein, is coupled to the lysine residues of other proteins. Ubiquitination is involved in many physiological events and promotescancer development and progression. This review elaborates the role of ubiquitin-specific protease (USP) in programmed cell death, which is common in breast cancer cells, and lays thefoundation for tumor diagnosis and targeted therapy.

关 键 词：ANOIKIS Apoptosis AUTOPHAGY Breast cancer Ferroptosis PYROPTOSIS Ubiquitin-specific proteases 

分 类 号：R737.9[医药卫生—肿瘤]