CHAPERONE

作品数：89被引量：271H指数：8
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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications被引量：1
《Neural Regeneration Research》2025年第10期2872-2886,共15页Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti 
supported by:Fondazione Telethon-Italy(No.GGP19128 to AP);Fondazione Cariplo-Italy(No.2021-1544 to RC);Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to AP;Target-RAN to AP);Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP);Kennedy’s Disease Association-USA(2018 grant to RC;2020 grant to MG);Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to AP;No.2022EFLFL8 to AP;No.2020PBS5MJ to VC;No.2022KSJZF5 to VC);PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC);CN3:RNA-Codice Proposta:CN_00000041;Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP);Progetto Dipartimenti di Eccellenza(to DiSFeB);Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP);Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).
Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...
关键词：AGGREGATION AUTOPHAGY cancer CHAPERONE chaperone-assisted selective autophagy cognitive impairment HSPB8 NEUROINFLAMMATION neuromuscular diseases therapy 
Targeting chaperone-mediated autophagy in neurodegenerative diseases:mechanisms and therapeutic potential
《Acta Pharmacologica Sinica》2025年第4期816-828,共13页Jin Wu Wan Xu Ying Su Guang-hui Wang Jing-jing Ma 
supported by the National Natural Science Foundation of China(grants 32400789 and 32070970);the Natural Science Foundation of Jiangsu Province(grants BK20240436);the Suzhou Science and Technology Development Plan(SZM2023006 and SKYD2023179);the Gusu Key Health Talent Program of Suzhou(GSWS2022122).
The pathological hallmarks of various neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease prominently feature the accumulation of misfolded proteins and neuroinflammation.Chaperone-media...
关键词：neurodegenerative diseases chaperone-mediated autophagy neuronal proteostasis NEUROINFLAMMATION CMA modulators 
ClpB chaperone as a promising target for antimicrobial therapy: A narrative review
《Asian Pacific Journal of Tropical Biomedicine》2025年第1期1-10,I0001-I0007,共17页Sachini J.Udari Sayoka Shamodhi Rumesh M.Nelumdeniya Udayana Ranatunga Nimesha N.Senadeera Chathuranga B.Ranaweera 
The Clp/Hsp100 family,part of the ATPase associated with various cellular activities(AAA+)superfamily,includes caseinolytic peptidase B(ClpB),a highly conserved protein found in bacteria,fungi,protozoa,and plants.Nota...
关键词：Molecular chaperone CLPB ESKAPE pathogens THERMOTOLERANCE Heat shock proteins Plasmodium falciparum 
The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics
《Journal of Biosciences and Medicines》2024年第8期347-356,共10页Robert B. Raffa Joseph V. Pergolizzi Jr. 
Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis...
关键词：CHAPERONE Sigma-1 Receptor ENERGETICS THERMODYNAMICS Isothermal Titration Microcalorimetry 
Chaperone-and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
《Cellular & Molecular Immunology》2024年第8期856-872,共17页Fenghao Geng Jianhui Chen Bin Song Zhicheng Tang Xiaoqian Li Shuaijun Zhang Tingyi Yang Yulan Liu Wei Mo Yining Zhang Chuntang Sun Lei Tan Wenling Tu Daojiang Yu Jianping Cao Shuyu Zhang 
National Natural Science Foundation of China 82073477(SZ),32071238(DY)and 82203973(FG);Scientific Fund for Distinguished Young Scholars in Sichuan Province 2022JDJQ0051(SZ)and 2022NSFSC0797(CS)and Young Talent Project of China National Nuclear Corporation(SZ).
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics,but the underlying mechanism remains poorly understood.Here,we revealed that the transcriptional activa...
关键词：Interferon regulatory factor 1(IRF1) Ionizing radiation Nuclear translocation Posttranslational modification(PTM) Transcription regulation 
金属纳米伴侣界面金属原子对淀粉样蛋白纤维化的调控作用
《Science China Materials》2024年第7期2345-2354,共10页李虎 高冠斌 余良翀 张子俊 张斌 邓昱周 慕庆雪 沈雷 孙涛垒 
We acknowledge the National Natural Science Foundation of China(52273110,21975191,52372271 and 22173070);the Youth Top Talent Project of Hubei Provence(GGB);the Knowledge Innovation Program of Wuhan-Shuguang Project(GGB);the Fundamental Research Funds for the Central Universities(WUT:2023III013GX)for financial supports.
合成具有生物分子伴侣功能的金属纳米伴侣作为调节蛋白质构象的候选物具有良好的应用前景.尽管对金属纳米伴侣已有广泛研究,但其分子中界面金属原子对蛋白质构象的调控作用及其机制尚不清楚,这严重阻碍了对高性能金属纳米伴侣的开发.本...
关键词：customizing nano-chaperone nano-interface gold-nanoclusters peptide amyloidosis 
Bcl-xL regulates radiation-induced ferroptosis through chaperone-mediated autophagy of GPX4 in tumor cells
《Radiation Medicine and Protection》2024年第2期90-99,共10页Jing Han Ruru Wang Bin Chen Feng Xu Liangchen Wei An Xu Lijun Wu Guoping Zhao 
the National Science Fund for Excellent Young Scholars(grant number 12122510);the National Natural Science Foundation of China(grant number 32171240);Anhui Provincial Natural Science Foundation(grant numbers 2108085MH279);the HFIPS Director’s Fund(grant numbers BJPY2021B07 and BJPY2023A010).
Objective:To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity.Methods:Reactive oxygen species(ROS)and lipid peroxide levels were detected in Mo...
关键词：BCL-XL Ferroptosis GPX4 Chaperone-mediated autophagy Lipid peroxidation 
Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases被引量：3
《Neural Regeneration Research》2024年第6期1291-1298,共8页Qi Jia Jin Li Xiaofeng Guo Yi Li You Wu Yuliang Peng Zongping Fang Xijing Zhang 
supported by the National Nature Science Foundation of China,Nos.81871603(to XZ)and 82171322(to ZF);Discipline Boost Program of the First Affiliated Hospital of Air Force Military Medical University,No.XJZT21J08(to XZ);the Natural Science Foundation of Shaanxi Province of China,No.2022KJXX-102(to ZF)。
Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins.Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular home...
关键词：chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis NEUROPROTECTION 
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2被引量：1
《Science China(Life Sciences)》2024年第6期1305-1307,共3页Songlin Gan Wen-Si Yang Liting Wei Zhiguo Zhang Rui-Ming Xu 
supported by the National Key Research and Development Program of China(2019YFA0508900);the National Natural Science Foundation of China(32330021,31991162,32200477);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37010100)。
Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin str...
关键词：STRUCTURE NUCLEOSOME passage 
Duality of jacalin-related lectin:Master regulator and chaperone
《Plant Communications》2024年第2期4-6,共3页Ganesh Alagarasan 
Lectins have chaperone-like activity with carbohydrate-binding sites,which are key in cellular homeostasis.However,the specific interactions between lectins and endoplasmic reticulum(ER)proteins during stress are uncl...
关键词：critical stress MASTER 
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