Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases  

作　　者：Qi Jia Jin Li Xiaofeng Guo Yi Li You Wu Yuliang Peng Zongping Fang Xijing Zhang 

机构地区：[1]Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit,Xijing Hospital,The Fourth Military Medical University,Xi’an,Shaanxi Province,China [2]Department of Critical Care Medicine,Air Force Medical Center,Beijing,China [3]Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Medicine,Tongji University,Shanghai,China

出　　处：《Neural Regeneration Research》2024年第6期1291-1298,共8页中国神经再生研究（英文版）

基　　金：supported by the National Nature Science Foundation of China,Nos.81871603(to XZ)and 82171322(to ZF);Discipline Boost Program of the First Affiliated Hospital of Air Force Military Medical University,No.XJZT21J08(to XZ);the Natural Science Foundation of Shaanxi Province of China,No.2022KJXX-102(to ZF)。

摘　　要：Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins.Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis,while providing nutrients and support for cell survival.Chaperone-mediated autophagy activity can be detected in almost all cells,including neurons.Owing to the extreme sensitivity of neurons to their environmental changes,maintaining neuronal homeostasis is critical for neuronal growth and survival.Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases.It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction.Under certain conditions,regulation of chaperone-mediated autophagy activity attenuates neurotoxicity.In this paper,we review the changes in chaperone-mediated autophagy in neurodegenerative diseases,brain injury,glioma,and autoimmune diseases.We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

关 键 词：chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis NEUROPROTECTION 

分 类 号：R741[医药卫生—神经病学与精神病学]