Unraveling the nutritional challenges in epilepsy:Risks,deficiencies,and management strategies:A systematic review  

作　　者：Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi 

机构地区：[1]Department of Pediatrics,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [2]Department of Pediatrics,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Bahrain [3]Medical Microbiology Section,Department of Pathology,Salmaniya Medical Complex,Governmental Hospitals,Manama 12,Bahrain [4]Medical Microbiology Section,Department of Pathology,The Royal College of Surgeons in Ireland,Busaiteen 15503,Muharraq,Bahrain [5]Department of Pulmonology,Faculty of Medicine,Tanta University,Tanta 31527,Alghrabia,Egypt [6]Department of Pulmonology,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Bahrain [7]Medicine,Royal College of Surgeons in Ireland,Medical University of Bahrain,Busaiteen 15503,Muharraq,Bahrain

出　　处：《World Journal of Experimental Medicine》2025年第2期200-245,共46页世界实验医学杂志(英文)

摘　　要：BACKGROUND Malnutrition and epilepsy share a complex bidirectional relationship,with malnutrition serving as a potential risk factor for epilepsy development,while epilepsy,in turn,often exerts profound effects on nutritional status.Nutritional interventions have emerged as a critical adjunctive approach in epilepsy management.AIM To explore the multifaceted associations between malnutrition and epilepsy,structured into three primary sections:(1)Elucidating the impact of malnutrition as a risk factor for epilepsy onset;(2)Examining the reciprocal influence of epilepsy on nutritional status,and(3)Evaluating diverse nutritional interventions in the management of epilepsy.METHODS A systematic search was conducted across PubMed,Scopus,and Web of Science databases utilizing defined keywords related to malnutrition,epilepsy,and nutritional interventions.Inclusion criteria encompassed various study types,including clinical trials,animal models,cohort studies,case reports,meta-analyses,systematic reviews,guidelines,editorials,and review articles.Four hundred sixteen pertinent references were identified,with 198 review articles,153 research studies,21 case reports,24 meta-analyses,14 systematic reviews,4 guidelines,and 2 editorials meeting the predefined criteria.RESULTS The review revealed the intricate interplay between malnutrition and epilepsy,highlighting malnutrition as a potential risk factor in epilepsy development and elucidating how epilepsy often leads to nutritional deficiencies.Findings underscored the importance of nutritional interventions in managing epilepsy,showing their impact on seizure frequency,neuronal function,and overall brain health.CONCLUSION This systematic review emphasizes the bidirectional relationship between malnutrition and epilepsy while emphasizing the critical role of nutritional management in epilepsy treatment.The multifaceted insights underscore the need for a holistic approach to addressing nutritional aspects alongside conventional epilepsy management strategies.

关 键 词：EPILEPSY Nutritional management Seizure disorders Antiepileptic drugs MINERALS L-CARNITINE VITAMINS Omega-3 Gut microbiota 

分 类 号：R742.1[医药卫生—神经病学与精神病学]