Context-dependent role of sirtuin 2 in inflammation  

作　　者：NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta 

机构地区：[1]Department of Pharmaceutical Sciences,Division of Pharmacology,School of Pharmacy and Nutrition,University of Navarra,Pamplona,Spain [2]Navarra Institute for Health Research(IdiSNA),Pamplona,Spain

出　　处：《Neural Regeneration Research》2025年第3期682-694,共13页中国神经再生研究（英文版）

基　　金：funded by FEDER/Ministerio de Ciencia,Innovación y Universidades Agencia Estatal de Investigación/Project(PID2020-119729GB-100,REF/AEI/10.13039/501100011033)(to EP);a predoctoral fellowship from the Spanish Ministry of Universities(FPU)and Amigos de la Universidad de Navarra(to NSS);“Programa MRR Investigo 2023”(to MGB and MMD)。

摘　　要：Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关 键 词：INTERFERON INFLAMMATION LIPOPOLYSACCHARIDE NEUROINFLAMMATION NLRP3 nuclear factorκB sirtuin 2 

分 类 号：R364.5[医药卫生—病理学]