Prognostic significance and underlying mechanisms of STING in lung adenocarcinoma  

作　　者：Haohua Zhu Yufeng Cao Jingyu Lu Lei Guo Rongrong Luo Huiyang Shi Yu Feng Yutao Liu Puyuan Xing Hongyu Wang Yuankai Shi Jie Ma Xingsheng Hu 

机构地区：[1]Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs,Chaoyang District,Beijing 100021,China [2]Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong 266033,China [3]Department of Pathology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Chaoyang District,Beijing 100021,China [4]Department of Laboratory Medicine,ZhuJiang Hospital of Southern Medical University,Guangzhou,Guangdong 510280,China [5]Department of Medical Oncology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China [6]Center of Biotherapy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Graduate School of Peking Union Medical College,Beijing 100730,China [7]Medical School,University of Chinese Academy of Sciences,Beijing 100049,China.

出　　处：《Chinese Medical Journal》2024年第20期2501-2503,共3页中华医学杂志(英文版)

基　　金：founded by Beijing Xisike Clinical Oncology Research Foundation(No.Y-2019AZMS-0439).

摘　　要：To the Editor:Genomic instability is a hallmark of cancer,with increasing genetic changes and DNA damage.The accumulated mutations in the tumor genome can generate neoantigens,which can trigger an antitumor immune response.Moreover,as a consequence of genomic instability,the leakage of nuclear DNA can directly alert the immune system to the presence of malignant cells.Cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)is a major DNA sensor that triggers the innate immune response.[1]The accumulation of doublestranded DNA fragments in the cytoplasm can directly bind to cGAS,functioning as an activator or stimulator of interferon genes(STING).STING acts as a signaling platform to recruit TANK-binding kinase 1(TBK1)and interferon regulatory factor 3(IRF3)for phosphorylation.Phosphorylated IRF3 translocates to the nuclei,where it functions as a transcription factor to promote the expression of type I interferon(IFN)and immune-stimulated cytokines.This leads to the migration and activation of various immune cells.

关 键 词：INTERFERON STIMULATOR ADENOCARCINOMA 

分 类 号：R73[医药卫生—肿瘤]