STING,a critical contributor to SARS-CoV-2 immunopathology  

作　　者：Heyu Li Fangfang Zhou Long Zhang 

机构地区：[1]School of Medicine,Zhejiang University City College,310015 Hangzhou,Zhejiang,China [2]Institutes of Biology and Medical Science,Soochow University,215123 Suzhou,China [3]MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,310058 Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第4期958-960,共3页信号转导与靶向治疗（英文）

基　　金：a special program from the Ministry of Science and Technology of China(2021YFA1101000);the Chinese National Natural Science Funds(31925013 and U20A20393 to L.Z.,31871405,32125016 and 82041009 to F.Z.);Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.);the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.);Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.);the Zhejiang Natural Science Fund(LD19C070001 to L.Z.);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);Adjunct Talent Fund of Zhejiang Provincial People's Hospital and A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。

摘　　要：Recently,a study published in Nature by Domizio et al.1 revealed the underlying mechanism of aberrant immunopathology during the late phase of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The authors provided evidence demonstrating that stimulator of interferon genes(STING)plays a unique role in the alveolus-capillary cytokine storm induced by mitochondrial DNA(mtDNA)during coronavirus disease 2019(COVID-19)(Fig.1).Some studies stressed that the STING agonists block the SARS-CoV-2 infection via triggering the type I interferons(IFNs)response,2,3 while others revealed that SARS-CoV-2 induces the chromatin DNA traveling to cytosol by promoting the cell-tocell fusion,resulting in the activation of cGAS-STING signaling.

关 键 词：INTERFERON STIMULATOR ACUTE 

分 类 号：R563.1[医药卫生—呼吸系统]