AUTOINFLAMMATION

作品数：8被引量：33H指数：3
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Primary cilia restrict autoinflammation by mediating PD-L1 expression
《Science Bulletin》2024年第16期2505-2508,共4页Xiaoyu Tian Kaiyue Zhang Renjie Hong Hanyu Wang Xifeng Dong Jun Zhou Yunfan Yang Min Liu 
supported by the National Natural Science Foundation of China(31991193,32000524,and 32100656);the National Key R&D Program of China(2021YFA1101001)。
Ciliopathies are multisystem disorders characterized by the dysfunction of motile and/or non-motile cilia,which are microtubule-based structures protruding from the cell surface and function in cell motility and signa...
关键词：INFLAMMATION ORGANS DEGENERATION 
RBP–RNA interactions in the control of autoimmunity and autoinflammation被引量：5
《Cell Research》2023年第2期97-115,共19页Juan Liu Xuetao Cao 
National Natural Science Foundation of China(32070903,31870909,81788101);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-017).
Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory responses toward self-components,contributing to various autoimmune diseases and autoinflammatory diseases.RNA-binding proteins(RBPs...
关键词：INFLAMMATION METABOLISM IMMUNITY 
Understanding the Pathogenesis of Generalized Pustular Psoriasis Based on Molecular Genetics and Immunopathology
《International Journal of Dermatology and Venereology》2022年第4期199-206,共8页An-Qi Zhao Ming Li 
Generalized pustular psoriasis(GPP)is a rare and life-threatening autoinflammatory skin disease characterized by recurrent and sudden episodes of widespread rashes with scattered sterile pustules.Clinical and genetic ...
关键词：AUTOINFLAMMATION generalized pustular psoriasis GPP genetic mechanisms IL-36 
MEFV,IRF8,ADA,PEPD,and NBAS gene variants and elevated serum cytokines in a patient with unilateral sporadic Meniere's disease and vascular congestion over the endolymphatic sac
《Journal of Otology》2022年第3期175-181,共7页Jing Zou Zikai Zhao Guoping Zhang Qing Zhang Ilmari Pyykko 
supported by the National Natural Science Foundation of China (81771006)
The etiology and underlying mechanism of Meniere's disease(MD)development are still unknown,although inflammation and autoimmunity have been implicated as underlying mechanisms.The human endolymphatic sac(ES)has been ...
关键词：Meniere's disease AUTOINFLAMMATION AUTOIMMUNE Immune organ Endolymphatic sac 
Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development被引量：1
《Cell Research》2022年第4期407-410,共4页Xinxin Zhu Na Yang Yu Yang Feiyang Yuan Dandan Yu Yu Zhang Zhaoqian Shu Ning Nan Hong Hu Xiaoyan Liu She Chen Liming Sun Huayi Wang 
supported by the National Natural Science Foundation of China(32050187 to L.S.,31571427 to H.W.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020402 and XDB19020112 to L.S.)。
Dear Editor,Necroptosis,a form of caspase-independent cell death,is tightly regulated to maintain tissue homeostasis.The execution of necroptosis depends on receptor interacting protein kinase 3(RIP3)-activated mixed ...
关键词：MLKL inflammation HOMEOSTASIS 
Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation
《Cellular & Molecular Immunology》2021年第7期1798-1808,共11页Sarang Tartey Prajwal Gurung Rajendra Karki Amanda Burton Paul Hertzog Thirumala-Devi Kanneganti 
supported by the K22 NIAID Career Transition Award Al 127836 to P.G.,the National Institutes of Health grants CAI 63507,AR056296,Al 124346 and AI101935 and by the American Lebanese Syrian Associated Charities to T.-D.K。
The SHP-1 protein encoded by the Ptpn6 gene has been extensively studied in hematopoietic cells in the context of inflammation.A point mutation in this gene(Ptpn6spin)causes spontaneous inflammation in mice,which has ...
关键词：AUTOINFLAMMATION ETS-2 IL-1Α Neutrophilic dermatoses PTPN6 SHP-1 
“Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis被引量：15
《Cellular & Molecular Immunology》2021年第2期307-317,共11页Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson 
This work was supported by the Babcock Endowment Fund(L.C.T.and J.E.G.),the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award numbers R01-AR060802(J.E.G.),P30-AR075043(J.E.G.),and K01-AR072129(L.C.T.),and the National Institute of Allergy and Infectious Diseases under award number R01-AR069071(J.E.G.),the A.Alfred Taubman Medical Research Institute(J.E.G.and J.M.K.),the National Psoriasis Foundation(J.E.G,N.L.W.,J.M.K.,E.M.,and L.C.T.),and the Parfait Emerging Scholar Award(J.M.K.).L.C.T.is supported by the Dermatology Foundation,the Arthritis National Research Foundation,and the National Psoriasis Foundation.
Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations.Plaque psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,domi...
关键词：Pustular psoriasis GENETICS IL-36 AUTOINFLAMMATION Clinical features HISTOLOGY 
The inflammasomes in health and disease:from genetics to molecular mechanisms of autoinflammation and beyond被引量：12
《Cellular & Molecular Immunology》2011年第2期135-145,共11页Cristina Conforti-Andreoni Paola Ricciardi-Castagnoli Alessandra Mortellaro 
This work was supported by Agency for Science,Technology and Research(A*STAR)of Singapore.
Nucleotide-binding oligomerization domain(NOD)-containing protein-like receptors(NLRs)are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response followi...
关键词：autoinflammatory diseases POLYMORPHISMS NLRS NLRP3 
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