RBP–RNA interactions in the control of autoimmunity and autoinflammation  

作　　者：Juan Liu Xuetao Cao 

机构地区：[1]National Key Laboratory of Medical Immunology,Institute of Immunology,Second Military Medical University,Shanghai,China [2]Department of Immunology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing,China [3]Frontier Research Center for Cell Response,Institute of Immunology,College of Life Sciences,Nankai University,Tianjin,China

出　　处：《Cell Research》2023年第2期97-115,共19页细胞研究（英文版）

基　　金：National Natural Science Foundation of China(32070903,31870909,81788101);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-017).

摘　　要：Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory responses toward self-components,contributing to various autoimmune diseases and autoinflammatory diseases.RNA-binding proteins(RBPs)are essential for immune cell development and function,mainly via exerting post-transcriptional regulation of RNA metabolism and function.Functional dysregulation of RBPs and abnormities in RNA metabolism are closely associated with multiple autoimmune or autoinflammatory disorders.Distinct RBPs play critical roles in aberrant autoreactive inflammatory responses via orchestrating a complex regulatory network consisting of DNAs,RNAs and proteins within immune cells.In-depth characterizations of RBP–RNA interactomes during autoimmunity and autoinflammation will lead to a better understanding of autoimmune pathogenesis and facilitate the development of effective therapeutic strategies.In this review,we summarize and discuss the functions of RBP–RNA interactions in controlling aberrant autoimmune inflammation and their potential as biomarkers and therapeutic targets.

关 键 词：INFLAMMATION METABOLISM IMMUNITY 

分 类 号：Q2[生物学—细胞生物学]