The inflammasomes in health and disease:from genetics to molecular mechanisms of autoinflammation and beyond  被引量:12

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作  者:Cristina Conforti-Andreoni Paola Ricciardi-Castagnoli Alessandra Mortellaro 

机构地区:[1]Singapore Immunology Network(SIgN),Agency for Science,Technology and Research(A*STAR),Immunos,Singapore

出  处:《Cellular & Molecular Immunology》2011年第2期135-145,共11页中国免疫学杂志(英文版)

基  金:This work was supported by Agency for Science,Technology and Research(A*STAR)of Singapore.

摘  要:Nucleotide-binding oligomerization domain(NOD)-containing protein-like receptors(NLRs)are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen recognition.Some NLRs form the framework for cytosolic platforms called inflammasomes,which orchestrate the early inflammatory process via IL-1b activation.Mutations and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a variety of autoinflammatory diseases.Moreover,the activity of certain inflammasomes is associated with susceptibility to infections as well as autoimmunity and tumorigenesis.In this review,we will discuss how identifying the genetic characteristics of inflammasomes is assisting our understanding of both autoinflammatory diseases as well as other immune system-driven disorders.

关 键 词:autoinflammatory diseases POLYMORPHISMS NLRS NLRP3 

分 类 号:R57[医药卫生—消化系统]

 

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