Primary cilia restrict autoinflammation by mediating PD-L1 expression  

初级纤毛通过介导PD-L1的表达限制自身炎症

作　　者：Xiaoyu Tian Kaiyue Zhang Renjie Hong Hanyu Wang Xifeng Dong Jun Zhou Yunfan Yang Min Liu 田晓宇;张凯悦;洪仁杰;王瀚钰;董喜凤;周军;杨云帆;刘敏

机构地区：[1]Center for Cell Structure and Function,Shandong Provincial Key Laboratory of Animal Resistance Biology,Haihe Laboratory of Cell Ecosystem,Collaborative Innovation Center of Cell Biology in Universities of Shandong,College of Life Sciences,Shandong Normal University,Jinan 250014,China [2]State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China [3]Department of Hematology,Tianjin Medical University General Hospital,Tianjin 300052,China [4]Department of Cell Biology,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan 250012,China [5]Laboratory of Tissue Homeostasis,Haihe Laboratory of Cell Ecosystem,Tianjin 300462,China

出　　处：《Science Bulletin》2024年第16期2505-2508,共4页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(31991193,32000524,and 32100656);the National Key R&D Program of China(2021YFA1101001)。

摘　　要：Ciliopathies are multisystem disorders characterized by the dysfunction of motile and/or non-motile cilia,which are microtubule-based structures protruding from the cell surface and function in cell motility and signaling.Common clinical manifestations of ciliopathies include retinal degeneration,mental retardation,renal abnormality,obesity,and skeletal dysplasia[1,2].Fibrosis of vital organs,characterized by the extensive deposition of extracellular matrix components,represents another complication frequently observed in patients and animal models of ciliopathies[3].

关 键 词：INFLAMMATION ORGANS DEGENERATION 

分 类 号：R363[医药卫生—病理学]