COVID-19,liver dysfunction and pathophysiology:A conceptual discussion  

作　　者：Jucier Gonçalves Júnior 

机构地区：[1]Department of Internal Medicine,Division of Rheumatology,São Paulo University,São Paulo 01246-903,State,Brazil

出　　处：《World Journal of Gastroenterology》2022年第6期683-688,共6页世界胃肠病学杂志（英文版）

摘　　要：The intra and extracellular pathways of hepatic injury by coronavirus disease 2019(COVID-19)are still being studied.Understanding them is important to treat this viral disease and other liver and biliary tract disorders.Thus,this paper aims to present three hypotheses about liver injury caused by COVID-19:(1)The interactions between severe acute respiratory syndrome coronavirus 2 spike protein and membrane receptors in the hepatocyte;(2)The dysbiosis and"gutliver axis"disruption in patients with serious clinical presentations of COVID-19;and(3)The inflammatory response exacerbated through the production of interleukins such as interleukin-6.However,despite these new perspectives,the pathophysiological process of liver injury caused by COVID-19 is still complex and multifactorial.Thus,understanding all these variables is a challenge to science but also the key to propose individualized and effective patient therapies.

关 键 词：COVID-19 Intracellular signaling peptides and proteins IMMUNOPATHOLOGY Liver diseases Liver injury SARS-CoV-2 

分 类 号：R57[医药卫生—消化系统]