supported by the National Natural Science Foundation of China under Grant 22376100.
Z-DNA binding protein 1(ZBP1)has emerged as a critical player in cancer biology,functioning as a cytosolic nucleic acid sensor that triggers PANoptosis,a form of programmed cell death that integrates pyroptosis,apopto...
supported by the grants from United Leukodystrophy Foundation(to Alessandro Michienzi);partially supported by the Italian Ministry of Health(No.GR-2019-12368701 to Davide Tonduti and Cristina Cereda).
Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis...
supported by the Basic research program of Natural Science in Shaanxi Province(No.2020JQ-466);Key research and development program of Shaanxi Province(No.2021SF-014);University Supporting Grant(No.2020rcfczr);Basic research project of the Logistics Support Department of the Chinese Military Commission(No.BWS21J002);National Natural Science Foundation of China(No.81871587).
apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure.We previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage dur...
supported by the National Natural Science Foundation of China(NSFC),China(Grant No 82170064,82241021 to Xiaowei Nie);Shenzhen Excellent Science and Technology Innovation Talent Development Programme,Shenzhen,China(Grant No.RCJC20210706091946002 to Xiaowei Nie);Shenzhen Science and Technology Program,Shenzhen,China(Grant No.JSGGZD20220822095200001 to Jin-Song Bian);China Postdoctoral Science Foundation,China(Grant No.2022M722212 to Junting Zhang).
Pulmonary hypertension(PH)is an extremely malignant pulmonary vascular disease of unknown etiology.ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine,thereby affecting RNA expression.However,the ...