Gut virome:New key players in the pathogenesis of inflammatory bowel disease  

作　　者：Helal F Hetta Rehab Ahmed Yasmin N Ramadan Hayam Fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem 

机构地区：[1]Department of Medical Microbiology and Immunology,Faculty of Medicine,Assiut University,Assiut 71515,Egypt [2]Division of Microbiology,Immunology and Biotechnology,Faculty of pharmacy,University of Tabuk,Tabuk 71491,Saudi Arabia [3]Division of Microbiology,Immunology and Biotechnology,Department of Natural Products and Alternative Medicine,Faculty of Pharmacy,University of Tabuk,Tabuk 71491,Saudi Arabia [4]Department of Internal Medicine,Division Hepatogastroenterology,Assiut University,Assiut 71515,Egypt [5]Department of Clinical Research,Egyptian Developers of Gastroenterology and Endoscopy Foundation,Cairo 11936,Egypt [6]Department of Internal Medicine,Faculty of Medicine.Tanta University,Tanta 31527,Egypt [7]Department of Tropical Medicine,Gastroenterology and Hepatology,Assiut University Hospital,Assiut 71515,Egypt

出　　处：《World Journal of Methodology》2025年第2期27-43,共17页世界方法学杂志（英文）

摘　　要：Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the intes-tine.While the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major determinants.The gut virome is a group of viruses found in great frequency in the gastrointestinal tract of humans.The gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and urbanization.The majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the microbiome.We conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关 键 词：Inflammatory bowel disease PATHOGENESIS Gut virome BACTERIOPHAGE Eukaryotic viruses 

分 类 号：R378[医药卫生—病原生物学]