Inflammatory bowel disease(IBD)is a progressive multifactorial inflammatory disease of the gut.The cause of IBD is yet unknown.Some researchers have shown that genetic factors,environmental factors,and the gut microbi...
Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the intes-tine.While the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immu...
funded by the Swedish Research Council[2021-02801 and 2023-03015];the Robert Bosch Foundation.
Two recent publications in Nature reveal the detailed structural mechanisms underlying the recognition of infection by the bacterial Phage Anti-Restriction Induced System(PARIS).1,2 These findings are important as the...
supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(No.BJ202205);the National Natural Science Foundation of China(Grant No.22376222);the Central South University Research Programme of Advanced Interdisciplinary Studies(Grant No.2023QYJC012);the Natural Science Foundation of Hunan Province(Grant No.2021JJ30864).
The coronavirus disease 2019(COVID-19)caused a large number of deaths and serious economic losses.Safety precautions and effective measures are urgently demanded to control the virus spread in public places.Owing to t...
supported by the National Natural Science Foundation of China(32230002);the National Key R&D Program of China(2020YFA0907200),and the Ba-Gui Scholar Program of Guangxi(To Z.G.H).
Insertion sequences(ISs)exist widely in bacterial genomes,but their roles in the evolution of bacterial antiphage defense remain to be clarified.Here,we report that,under the pressure of phage infection,the IS1o96 tra...
funded by the the National Key Research and development Project of China(grant no.2022YFA1304300);National Natural Science Foundation of China(grant no.81971896).
Carbapenem-resistant Klebsiella pneumoniae(CRKP)is emerging as an imminent threat to worldwide public health because of its high level of antimicrobial resistance,which can result in severe and challenging-to-treat in...
This work was supported by the Western Medicine Program of the Zhejiang Provincial Health Commission(No.2024KY592);the Fundamental Research Funds for Central Universities of the Central South University(No.2-2050205-19-361),China.
In the post-antibiotic era,the overuse of antimicrobials has led to a massive increase in antimicrobial resistance,leaving medical doctors few or no treatment options to fight infections caused by superbugs.The use of...
Funding was provided by the National Natural Science Foundation of China(Grant No.22078042).
As an alternative to antibiotics in response to antimicrobial-resistant infections,bacteriophages(phages)are garnering renewed interest in recent years.However,the massive preparation of phage is restricted using trad...
This work was supported by the University Grants Committee,Hong Kong SAR Government(No.14112921,China).The support of HKPFS from the University Grants Committee to HonglanWang was greatly acknowledged.
Predatory bacteriophages have evolved a vast array of depolymerases for bacteria capture and deprotection.These depolymerases are enzymes responsible for degrading diverse bacterial surface carbohydrates.They are expl...
Inappropriate use of antibiotics is globally creating public health hazards associated with antibiotic resistance.Bacteria often acquire antibiotic resistance by altering their genes through mutation or acquisition of...