Neuroinflammation revisited through the microglial lens  

作　　者：Renato Socodato João B.Relvas 

机构地区：[1]Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC),University of Porto,Porto,Portugal [2]Department of Biomedicine,Faculty of Medicine of the University of Porto(FMUP),Porto,Portugal

出　　处：《Neural Regeneration Research》2025年第7期1989-1990,共2页中国神经再生研究（英文版）

基　　金：funded by Portuguese funds through FCT——Funda??o para a Ciência e a Tecnologia/Ministério da Ciência,Tecnologia e Ensino Superior in the framework of the project PTDC/MEDNEU/1677/2021(to JBR)。

摘　　要：Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune system.This exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new therapies.We challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial activation.By dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s progression.This article calls for a significant paradigm shift towards an integrative,multi-omics approach to neuroimmunology.Adopting such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关 键 词：INFLAMMATION simplified ACTIVATION 

分 类 号：R741[医药卫生—神经病学与精神病学]