IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses  

作　　者：Xinmin Qian Meiyi Tong Tianqing Zhang Qingqing Li Meng Hua Nan Zhou Wenwen Zeng 

机构地区：[1]Institute for Immunology and School of Basic Medical Sciences,Tsinghua Medicine,Tsinghua University,Beijing 100084,China [2]SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine,Shanxi Medical University,Taiyuan 030001,China [3]Eight-year Medical Doctor Program,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100084,China [4]School of Life Sciences,Tsinghua University,Beijing 100084,China [5]Tsinghua-Peking Center for Life Sciences,Beijing 100084,China [6]Beijing Key Laboratory for Immunological Research on Chronic Diseases,Beijing 100084,China

出　　处：《Protein & Cell》2025年第3期188-210,共23页蛋白质与细胞(英文版)

基　　金：supported by the National Key R&D Program of China(2023YFC2306300);the National Natural Science Foundation of China(Grant Nos.32225019,92357304,and 32394003);supported by the Center for Life Sciences,the Institute for Immunology,and School of Basic Medical Sciences at Tsinghua University.

摘　　要：Atopic dermatitis(AD)is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching.The colonization of Staphylococcus aureus(S.aureus)is correlated with the severity of the disease,but its role in AD development remains elusive.Using single-cell RNA sequencing,we uncovered that keratinocytes activate a distinct immune response characterized by induction of Il24 when exposed to methicillin-resistant S.aureus(MRSA).Further experiments using animal models showed that the administration of recombinant IL-24 protein worsened AD-like pathology.Genetic ablation of Il24 or the receptor Il20rb in keratinocytes alleviated allergic inflammation and atopic march.Mechanistically,IL-24 acted through its heterodimeric receptors on keratinocytes and augmented the production of IL-33,which in turn aggravated type 2 immunity and AD-like skin conditions.Overall,these findings establish IL-24 as a critical factor for onset and progression of AD and a compelling therapeutic target.

关 键 词：IL-24 atopic dermatitis MRSA KERATINOCYTES allergic inflammation 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]