Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways  

作　　者：Zhong-Yuan Hu Ding Ding Yu Song Ya-Feng Deng Cheng-Ming Zhang Tao Yu 

机构地区：[1]First School of Clinical Medicine,Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi Province,China [2]College of Acupuncture and Massage,Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi Province,China [3]Graduate School,Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong Province,China [4]Digestive Department I,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi’an 710000,Shaanxi Province,China

出　　处：《World Journal of Clinical Oncology》2025年第2期18-28,共11页世界临床肿瘤学杂志（英文）

基　　金：Supported by National Key Research and Development Program Project,No.2017YFC1700601;Shaanxi Provincial Key Research and Development Program Project,No.2018SF-350;Leading Talents in Scientific and Technological Innovation of the Shaanxi Province Special Support Plan,No.00518。

摘　　要：Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival rate.This study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease progression.In particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic strategies.This study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic regimens.Future studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关 键 词：Pancreatic cancer FIBROBLASTS Signaling pathways Tumor microenvironment 

分 类 号：R735.9[医药卫生—肿瘤]