Optical-neural Stimulation in Non-human Primates:Modulating Brain Function and Behavior  

非人灵长类的光学神经调控:脑功能和行为的调节

作　　者：CHEN Yi-Bing WANG Huan YANG Yan 陈怡冰;王欢;杨艳(中国科学院生物物理研究所,脑与认知科学国家重点实验室,北京100101;中国科学院大学中丹学院,北京100049)

机构地区：[1]State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [2]Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《生物化学与生物物理进展》2024年第10期2379-2391,共13页Progress In Biochemistry and Biophysics

基　　金：国家重点研发计划(2022YFB4700101);科技创新2030-“脑科学与类脑研究”重大项目(2022ZD0204800);国家自然科学基金(32070987)资助。

摘　　要：Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.光学神经调控技术,包括光遗传学和红外光神经刺激,可通过不同机制有效调节大脑功能和行为。这些前沿技术能够精确地操控大脑特定区域,选择性地调控特定神经元的活动,从而探究神经活动与行为之间的因果关系,更深入地理解大脑在复杂环境中的动态活动。非人灵长类动物作为研究这些复杂大脑功能的重要模型,起到了连接基础研究与临床应用的桥梁作用。自2009年科学家在猕猴上应用光遗传学进行光学神经调控以来,这些技术已在非人灵长类动物中得到了有效验证和应用。本文综述了近年来利用光遗传学和红外神经刺激技术调节非人灵长类动物大脑功能和行为的最新研究进展,并讨论了当前光学神经调控技术的应用现状,强调了其对于推动解析大脑功能的重要性。同时也探讨了光学神经调控技术在非人灵长类上的进一步研究和应用所面临的挑战。

关 键 词：optical-neural stimulation OPTOGENETICS infrared neurostimulation non-human primates 

分 类 号：B842.1[哲学宗教—基础心理学]