Enhanced neurogenesis after ischemic stroke:The interplay between endogenous and exogenous stem cells  

作　　者：Ruxu Geng Yuhe Wang Renzhi Wang Jun Wu Xinjie Bao 

机构地区：[1]Department of Neurosurgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China [2]Stanford Cancer Institute,Stanford University,Stanford,CA,USA [3]State Key Laboratory of Common Mechanism Research for Major Diseases,Beijing,China

出　　处：《Neural Regeneration Research》2026年第1期212-223,共12页中国神经再生研究(英文版)

基　　金：supported by the National Key Research and Development Program of China,No.2018YFA0108602;the CAMS Initiative for Innovative Medicine,No.2021-1-I2M-019;National High-Level Hospital Clinical Research Funding,No.2022-PUMCH-C-042(all to XB)。

摘　　要：Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within the ischemic brain,these mechanisms are often insufficient to restore neuronal functionality.This has led to intensive investigation into the use of exogenous stem cells as a potential therapeutic option.This comprehensive review outlines the ontogeny and mechanisms of activation of endogenous neural stem cells within the adult brain following ischemic events,with focus on the impact of stem cell-based therapies on neural stem cells.Exogenous stem cells have been shown to enhance the proliferation of endogenous neural stem cells via direct cell-tocell contact and through the secretion of growth factors and exosomes.Additionally,implanted stem cells may recruit host stem cells from their niches to the infarct area by establishing so-called“biobridges.”Furthermore,xenogeneic and allogeneic stem cells can modify the microenvironment of the infarcted brain tissue through immunomodulatory and angiogenic effects,thereby supporting endogenous neuroregeneration.Given the convergence of regulatory pathways between exogenous and endogenous stem cells and the necessity for a supportive microenvironment,we discuss three strategies to simultaneously enhance the therapeutic efficacy of both cell types.These approaches include:(1)co-administration of various growth factors and pharmacological agents alongside stem cell transplantation to reduce stem cell apoptosis;(2)synergistic administration of stem cells and their exosomes to amplify paracrine effects;and(3)integration of stem cells within hydrogels,which provide a protective scaffold for the implanted cells while facilitating the regeneration of neural tissue and the reconstitution of neural circuits.This comprehensive review highlights the interactions and shared regulatory mechanisms between endogenous neural stem cells and exogenously implanted stem cells

关 键 词：brain-derived neurotrophic factor endogenous neuroregeneration exosomes hydrogels ischemic stroke mesenchymal stem cells neural stem cells NEUROGENESIS stem cell transplantation 

分 类 号：R73[医药卫生—肿瘤]